| Identification | More | [Name]
1-Bromo-4-iodobenzene | [CAS]
589-87-7 | [Synonyms]
1-BROMO-4-IODOBENZENE
4-BROMO-1-IODOBENZENE
4-BROMOIODOBENZENE
4-IODOBROMOBENZENE
P-BROMOIODOBENZENE
1-bromo-4-iodo-benzen
p-Bromophenyl iodide
p-Iodobromobenzene
1-bromo-4-oiodobenzene
p-Bromoiodobenzene 1-Bromo-4-Iodo Benzene
p-Bromiodobenzene
1-BROMO-IODOBENZENE
1-Bromo-4-Iodobenzene>99%
1-Bromo-4-iodobenzene, 97+%
1-Bromo-4-iodobenzene,98%
4-Bromophenyl iodide
4-Iodo-1-bromobenzene
4-Iodophenyl bromide | [EINECS(EC#)]
209-662-7 | [Molecular Formula]
C6H4BrI | [MDL Number]
MFCD00001051 | [Molecular Weight]
282.9 | [MOL File]
589-87-7.mol |
| Chemical Properties | Back Directory | [Appearance]
white to brown cryst. powder, crystals or needles | [Melting point ]
89-91 °C(lit.)
| [Boiling point ]
120-122 °C14 mm Hg(lit.)
| [density ]
2.2236 (rough estimate) | [refractive index ]
1.6618 (estimate) | [Fp ]
120-122°C/14mm | [storage temp. ]
Store below +30°C. | [solubility ]
0.008g/l | [form ]
Crystalline Powder, Crystals or Needles | [color ]
White to brown | [Water Solubility ]
Insoluble in water. | [Sensitive ]
Light Sensitive | [BRN ]
1904545 | [InChI]
1S/C6H4BrI/c7-5-1-3-6(8)4-2-5/h1-4H | [InChIKey]
UCCUXODGPMAHRL-UHFFFAOYSA-N | [SMILES]
Brc1ccc(I)cc1 | [CAS DataBase Reference]
589-87-7(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzene, 1-bromo-4-iodo-(589-87-7) | [EPA Substance Registry System]
589-87-7(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319 | [Precautionary statements ]
P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [Hazard Note ]
Harmful/Light Sensitive | [TSCA ]
T | [HazardClass ]
IRRITANT, LIGHT SENSITIVE, IRRITANT-HARMFUL | [HS Code ]
29036990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2 |
| Hazard Information | Back Directory | [Chemical Properties]
white to brown cryst. powder, crystals or needles | [General Description]
Vapour pressure as a function of temperature for 1-bromo-4-iodobenzene has been studied using a diaphragm manometer and torsion mass-loss effusion. | [Synthesis]
The p-bromoiodobenzene was synthesized by diazotization and iodination using industrial p-bromoaniline as raw material. The better synthesis conditions: firstly, 0.02 mol of p-bromoaniline was dissolved in 20% sulfuric acid, and reacted with 0.021 mol of |
| Questions And Answer | Back Directory | [Synthesis methods]
Industrial parabromoaniline is as raw material, by diazotization, iodo-synthesis of bromo iodobenzene. Preferred synthesis conditions: firstly 0.02mol parabromoaniline is dissolved in a mass fraction of 20% sulfuric acid medium, then reacts with 0.021molNaNO2 to generate bromophenyl diazonium sulfate at-10℃, and then chloroform and 0.021molKI is added into solution to process iodination reaction, after simple treatment bromo-iodobenzene crude product (which the bromo-iodobenzene HPLC purity 98.4%) is obtained, total yield after purification is 80%, increases by 15% than before improved. The product processes structural characterization by IR and 1HNMR. The improved method can greatly improve the purity of the crude product, this avoids the trouble of going through the column, this method is safe and easy to operate, easy to control the process, cost is lower, it is more suitable for the preparation of 1-Bromo-4-iodobenzene.
Unit: Heilongjiang University of Chemistry and Materials Science
Author: Guo Jing Bai Xuefeng Lvhong Fei | [Uses]
1. 1-Bromo-4-iodobenzene is used for organic synthesis.
2. Used as substrate for copper-free Sonogashira coupling reaction in aqueous acetone.
3. For the synthesis of β,β-dibromostyrene. |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
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Alfa Aesar
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http://chemicals.thermofisher.cn |
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