402-43-7

N-Methyl-2-pyrrolidone (NMP) (50 mL) was added to 1-bromo-4-iodobenzene (1 equivalent, 1278 mg, 4.42 mmol), cuprous iodide (I) (1.5 equivalent, 1263 mg, 6.63 mmol), and 2-fluorosulfonyl difluoroacetic acid (5 equivalent, 4249 mg, 2.82 mL, 22.12 mmol). The brown reaction mixture was heated and stirred at 80°C for 16 hours under an argon atmosphere. The reaction mixture was diluted with diethyl ether (25 mL) and filtered through diatomaceous earth. Water was added to the filtrate, and the aqueous layer was extracted with diethyl ether (4 × 25 mL). The organic layer was washed with water (2 × 25 mL) and brine, dried over MgSO₄, and concentrated under reduced pressure.