| Identification | Back Directory | [Name]
NSC 361680 | [CAS]
5961-83-1 | [Synonyms]
NSC 361680
Bis-PEG1-acid
CAS_5961-83-1
Bis-PEG1-COOH
3,3'-oxydipropanoic acid
3,3'-Oxydipropionic acid
Bis(2-carboxyethyl) ether
3,3'-Oxybis[propanoic acid]
Propanoic acid, 3,3'-oxybis-
3-(2-carboxyethoxy)propionic acid
3-(2-carboxyethoxy)propanoic acid
3-(2-carboxyethyloxy)propanoic acid | [Molecular Formula]
C6H10O5 | [MDL Number]
MFCD06208032 | [MOL File]
5961-83-1.mol | [Molecular Weight]
162.14 |
| Chemical Properties | Back Directory | [Melting point ]
60-61 °C | [Boiling point ]
198-200 °C(Press: 1-2 Torr) | [density ]
1.316±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer, Under inert atmosphere | [solubility ]
Aqueous Base (Slightly), Chloroform (Slightly), Methanol (Slightly), Water (Slightly) | [form ]
Solid | [pka]
3.96±0.10(Predicted) | [color ]
Pale Yellow to Light Yellow | [InChI]
InChI=1S/C6H10O5/c7-5(8)1-3-11-4-2-6(9)10/h1-4H2,(H,7,8)(H,9,10) | [InChIKey]
FOSIWKADJDNVMJ-UHFFFAOYSA-N | [SMILES]
O(CCC(O)=O)CCC(O)=O |
| Hazard Information | Back Directory | [Description]
Bis-PEG1-acid is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Uses]
Bis-PEG1-acid is a PEG-based PROTAC linker and can be used in the synthesis of PROTACs as BCL-xL degraders and anticancer agents with low platelet toxicity. | [IC 50]
PEGs |
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| Company Name: |
Cool Pharm, Ltd
|
| Tel: |
021-60455363 18019463053 |
| Website: |
www.coolpharm.com |
|