| Identification | More | [Name]
Theophylline monohydrate | [CAS]
5967-84-0 | [Synonyms]
1,3-DIMETHYLXANTHINE
THEOPHYLLINE MONOHYDRATE
Theophyline monohydrate
Theophylline hydrous
Theophyllinemonohydrate,99%
1,3-Dimethylxanthine monohydrate
1,3-Dimethyl-7H-purine-2,6-dione hydrate
1,3-Dimethyl-1H-purine-2,6(3H,7H)-dione·hydrate | [EINECS(EC#)]
200-385-7 | [Molecular Formula]
C7H10N4O3 | [MDL Number]
MFCD00151659 | [Molecular Weight]
198.18 | [MOL File]
5967-84-0.mol |
| Chemical Properties | Back Directory | [Appearance]
White or almost white, crystalline powder. | [Melting point ]
270-274°C | [RTECS ]
XH3850000 | [solubility ]
Slightly soluble in water, sparingly soluble in ethanol (96 per cent). It dissolves in solutions of alkali hydroxides, in ammonia and in mineral acids. | [Water Solubility ]
Soluble in water (8 g/L at 20°C). | [Merck ]
14,9285 | [BRN ]
13463 | [CAS DataBase Reference]
5967-84-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Risk Statements ]
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S22:Do not breathe dust .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
2811 | [TSCA ]
Yes | [HazardClass ]
6.1 |
| Hazard Information | Back Directory | [Chemical Properties]
White or almost white, crystalline powder. | [Uses]
Bronchodilatator;Mastocyte degranulation inhibitor in vitro | [Uses]
Theophylline monohydrate is a methylxanthine drug used in therapy for respiratory diseases such as COPD and asthma | [in vivo]
Theophylline (1,3-Dimethylxanthine) (100 mg/kg; i.p.; daily, for 9 d; male Swiss mice) has anti-inflammatory activity in mice and increases IL-6 and IL-10 levels and inhibits TNF-α and NO[1]. | Animal Model: | Male Swiss mice[1] | | Dosage: | 100 mg/kg | | Administration: | Intraperitoneal injection; daily, for 9 days | | Result: | Increased IL-6 and IL-10 levels and inhibited TNF-α and NO. |
| [IC 50]
IL-10; IL-6; PDE3; Human Endogenous Metabolite |
|
| Company Name: |
Alfa Aesar
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| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
AFINE CHEMICALS LIMITED
|
| Telephone: |
+86-571-85134551 +86-18958018566 |
| Website: |
www.afinechem.com/index.html |
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