ChemicalBook--->CAS DataBase List--->5988-19-2

5988-19-2

5988-19-2 Structure

5988-19-2 Structure
IdentificationMore
[Name]

L-DIHYDROOROTIC ACID
[CAS]

5988-19-2
[Synonyms]

DIHYDRO-L-OROTIC ACID
L-DIHYDROOROTIC ACID
L-HYDROOROTIC ACID
(S)-(+)-HYDROOROTIC ACID
(S)-2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid
2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid
L-4,5-Dihydroorotic acid~(S)-(+)-2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid
(4S)-2,6-dioxo-1,3-diazinane-4-carboxylic acid
(S)-Dihydroorotate
(S)-2,6-dioxohexahydropyrimidine-4-carboxylic acid
Adenosine-5'-diphosphoric acid Na2
Adenosine-5-triphosphoric acid Na2
Deoxyribonucein acid(fish sperm)
DNTPS
Guanosine-5-diphosphate disodiun
Guanosine-5-monophosphate disodiun
Guanosine-5'-triphosphate disodiun
Inosine-5-triphosphate trisodium
Ribonuclein acid,yeast
t-Ribonuclein acid,yeast
[EINECS(EC#)]

624-952-7
[Molecular Formula]

C5H6N2O4
[MDL Number]

MFCD00085339
[Molecular Weight]

158.11
[MOL File]

5988-19-2.mol
Chemical PropertiesBack Directory
[Appearance]

White to off-white crystalline powder
[Melting point ]

254-255 °C (dec.)(lit.)
[Boiling point ]

283.16°C (rough estimate)
[density ]

1.523
[refractive index ]

1.5090 (estimate)
[storage temp. ]

Store at 0-5°C
[solubility ]

DMSO (Slightly), Water (Slightly, Heated, Sonicated)
[form ]

Powder
[pka]

2.82±0.20(Predicted)
[color ]

White to off-white
[Water Solubility ]

Soluble in water (partly), and dimethyl formamide.
[InChIKey]

UFIVEPVSAGBUSI-REOHCLBHSA-N
[CAS DataBase Reference]

5988-19-2(CAS DataBase Reference)
[NIST Chemistry Reference]

Orotic acid, dihydro-, l-(5988-19-2)
Safety DataBack Directory
[Hazard Codes ]

Xi
[Risk Statements ]

R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
[WGK Germany ]

3
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Orotic acid
[Preparation Products]

Disodium 5'-Inosinate-->Ribavirin-->CALCIUM5'-RIBONUCLEOTIDES-->Idoxuridine
Hazard InformationBack Directory
[Chemical Properties]

White to off-white crystalline powder
[Uses]

L-Dihydroorotic acid a metabolite.
[Definition]

ChEBI:(S)-dihydroorotic acid is the (S)-enantiomer of dihydroorotic acid that is an intermediate in the metabolism of pyridine. It has a role as a Saccharomyces cerevisiae metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a (S)-dihydroorotate. It is an enantiomer of a (R)-dihydroorotic acid.
[Biochem/physiol Actions]

L-Dihydroorotic acid (DHO) serves as a substrate for dihydroorotate dehydrogenase (DHODH), an enzyme in the de novo synthesis of pyrimidine. Inhibition of DHOH by its inhibitors causes a large accumulation of upstream metabolite DHO and a reduction in the uridine levels. Therefore, DHO and uridine can be used as biomarkers for pyrimidine synthesis for the clinical development of DHOH inhibitors.
[storage]

Store at 2-8°C
Spectrum DetailBack Directory
[Spectrum Detail]

L-DIHYDROOROTIC ACID(5988-19-2)MS
L-DIHYDROOROTIC ACID(5988-19-2)1HNMR
L-DIHYDROOROTIC ACID(5988-19-2)13CNMR
L-DIHYDROOROTIC ACID(5988-19-2)IR1
L-DIHYDROOROTIC ACID(5988-19-2)IR2
L-DIHYDROOROTIC ACID(5988-19-2)Raman
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

5988-19-2(sigmaaldrich)
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