| Identification | More | [Name]
L-DIHYDROOROTIC ACID | [CAS]
5988-19-2 | [Synonyms]
DIHYDRO-L-OROTIC ACID
L-DIHYDROOROTIC ACID
L-HYDROOROTIC ACID
(S)-(+)-HYDROOROTIC ACID
(S)-2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid
2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid
L-4,5-Dihydroorotic acid~(S)-(+)-2,6-Dioxohexahydro-4-pyrimidinecarboxylic acid
(4S)-2,6-dioxo-1,3-diazinane-4-carboxylic acid
(S)-Dihydroorotate
(S)-2,6-dioxohexahydropyrimidine-4-carboxylic acid
Adenosine-5'-diphosphoric acid Na2
Adenosine-5-triphosphoric acid Na2
Deoxyribonucein acid(fish sperm)
DNTPS
Guanosine-5-diphosphate disodiun
Guanosine-5-monophosphate disodiun
Guanosine-5'-triphosphate disodiun
Inosine-5-triphosphate trisodium
Ribonuclein acid,yeast
t-Ribonuclein acid,yeast | [EINECS(EC#)]
624-952-7 | [Molecular Formula]
C5H6N2O4 | [MDL Number]
MFCD00085339 | [Molecular Weight]
158.11 | [MOL File]
5988-19-2.mol |
| Chemical Properties | Back Directory | [Appearance]
White to off-white crystalline powder | [Melting point ]
254-255 °C (dec.)(lit.)
| [Boiling point ]
283.16°C (rough estimate) | [density ]
1.523 | [refractive index ]
1.5090 (estimate) | [storage temp. ]
Store at 0-5°C | [solubility ]
DMSO (Slightly), Water (Slightly, Heated, Sonicated) | [form ]
Powder | [pka]
2.82±0.20(Predicted) | [color ]
White to off-white | [Water Solubility ]
Soluble in water (partly), and dimethyl formamide. | [InChI]
InChI=1S/C5H6N2O4/c8-3-1-2(4(9)10)6-5(11)7-3/h2H,1H2,(H,9,10)(H2,6,7,8,11)/t2-/m0/s1 | [InChIKey]
UFIVEPVSAGBUSI-REOHCLBHSA-N | [SMILES]
C1(=O)NC(=O)C[C@@H](C(O)=O)N1 | [CAS DataBase Reference]
5988-19-2(CAS DataBase Reference) | [NIST Chemistry Reference]
Orotic acid, dihydro-, l-(5988-19-2) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
|
| Hazard Information | Back Directory | [Chemical Properties]
White to off-white crystalline powder | [Uses]
L-Dihydroorotic acid a metabolite. | [Definition]
ChEBI:(S)-dihydroorotic acid is the (S)-enantiomer of dihydroorotic acid that is an intermediate in the metabolism of pyridine. It has a role as a Saccharomyces cerevisiae metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a conjugate acid of a (S)-dihydroorotate. It is an enantiomer of a (R)-dihydroorotic acid. | [Biochem/physiol Actions]
L-Dihydroorotic acid (DHO) serves as a substrate for dihydroorotate dehydrogenase (DHODH), an enzyme in the de novo synthesis of pyrimidine. Inhibition of DHOH by its inhibitors causes a large accumulation of upstream metabolite DHO and a reduction in the uridine levels. Therefore, DHO and uridine can be used as biomarkers for pyrimidine synthesis for the clinical development of DHOH inhibitors. | [IC 50]
Microbial Metabolite; Human Endogenous Metabolite | [storage]
Store at 2-8°C |
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| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
RYSS TECH LTD
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| Telephone: |
400-188-0725 +86 21 34310725 13611771617 |
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www.chemicalbook.com/ShowSupplierProductsList15256/0_EN.htm |
| Company Name: |
Spectrum Chemical Manufacturing Corp.
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| Telephone: |
021-021-021-67601398-809-809-809 15221380277 |
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www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
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