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Ribavirin Suppliers list
Company Name: Hebei Guanlang Biotechnology Co., Ltd.
Tel: +86-0311-66562153 whatsapp +8615203118427
Products Intro: Product Name:Ribavirin
Purity:99% Package:Packaging(Various Packaging) Remarks:email: whatsapp/wechat: +8615203118427 skype:
Company Name: Capot Chemical Co.,Ltd.
Tel: +86 (0)571-855 867 18
Products Intro: Product Name:1-beta-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Shenzhen Sendi Biotechnology Co.Ltd.
Tel: 0755-23311925 18102838259
Products Intro: Product Name:Ribavirin
Purity:99% Package:314/KG
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Products Intro: Product Name:Ribavirin
Purity:99.00% Package:100g,500g,1KG,10KG,100KG
Company Name: Shanghai Bojing Chemical Co.,Ltd.
Tel: +86-21-37122233
Products Intro: Product Name:Ribavirin
Purity:99% Package:1kg;25kg;200kg Cardboard barrels Remarks:colorless crystalline

Lastest Price from Ribavirin manufacturers

  • Ribavirin
  • US $1.00 / kg
  • 2018-12-17
  • CAS:36791-04-5
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: Customized
Ribavirin Basic information
Antiviral drugs Pharmacological effects Chemical Properties Uses Production method
Product Name:Ribavirin
Synonyms:1-β-D-RIBOFURANOSYL-1H-1, 2, 4-TRIAZOLE-3-CARBOXAMIDE (RIBAVIRIN);1--D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide;Ribavirin-13C2;1-β-D-ribofuranozyl-1H-1,2,4-triazole-3-carboxamide;RTC;virazol;NSC-163039;Ribavirin,1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
Product Categories:Antivirals for Research and Experimental Use;Biochemistry;Chemical Reagents for Pharmacology Research;Nucleosides and their analogs;Nucleosides, Nucleotides & Related Reagents;Anti-virals;Inhibitors;Intermediates & Fine Chemicals;Non-nucleoside Reverse Transcriptase;Pharmaceuticals;API's;Antiviral;Bases & Related Reagents;Carbohydrates & Derivatives;Nucleotides;Active Pharmaceutical Ingredients
Mol File:36791-04-5.mol
Ribavirin Structure
Ribavirin Chemical Properties
Melting point 174-176°C
alpha D25 -36.5° (c = 1 in water); D20 -38° (c = 1 in water)
Boiling point 387.12°C (rough estimate)
density 1.4287 (rough estimate)
refractive index -36 ° (C=1, H2O)
storage temp. 2-8°C
solubility Freely soluble in water, slightly soluble in ethanol (96 per cent), slightly soluble or very slightly soluble in methylene chloride. It shows polymorphism (5.9).
form White solid
Water Solubility >=10 g/100 mL at 19 ºC
Merck 14,8198
CAS DataBase Reference36791-04-5
EPA Substance Registry System1H-1,2,4-Triazole- 3-carboxamide, 1-.beta.-D-ribofuranosyl-(36791-04-5)
Safety Information
Hazard Codes T,Xi
Risk Statements 61-36/38
Safety Statements 53-22-45-37/39-26
WGK Germany 3
RTECS XZ4250000
HS Code 29349990
Hazardous Substances Data36791-04-5(Hazardous Substances Data)
ToxicityLD50 i.p. in mice: 1.3 g/kg; orally in rats: 5.3 g/kg (Witkowski, 1972)
MSDS Information
Ribavirin Usage And Synthesis
Antiviral drugsRibavirin is a novel non-selective nucleoside class broad-spectrum antiviral drug, belonging to the inosine monophosphate (IMP) dehydrogenase inhibitor. It can participate in the guanine participate in the human body metabolism, interfere with the biosynthesis of guanine, prevent the replication of the virus and has inhibitory effect on a variety of DNA and RNA viruses. Ribavirin has a stronger antiviral effect than amantadine and vidarabine, etc with definite efficacy and small drug side effects. Rare adverse reactions include conjunctivitis and hypotension with the former exhibiting as intraocular foreign body sensation, photophobia, itching, swelling and hematoma and the latter manifested as blurred vision, dizziness, and fatigue. It is used for clinical treatment of viral upper respiratory tract infection, respiratory syncytial virus-induced viral pneumonia and bronchitis, influenza, para-influenza, epidemic encephalris, mumps, chickenpox, shingles, herpes zoster, autumn diarrhea, children early-stage adenovirus pneumonia, acute Lassa fever, rubella, viral pneumonia, genital herpes, herpes simplex virus keratitis, psoriasis, etc with special efficacy. It also have certain efficacy on treating epidemic hemorrhagic fever, hepatitis B, and hepatitis A. Applying this drug in early stage of epidemic hemorrhagic fever can shorten the period, reducing the damage of kidney and vascular and symptoms of poisoning.
Pharmacological effects1, Ribavirin can be subject to phosphorylation in red blood cells to generate ribavirin monophosphate, diphosphate and triphosphate, wherein the ribavirin monophosphate is the strong inhibitor of the inosine monophosphate dehydrogenase which can inhibit cellular guanylate synthesis, decrease the tri-phosphorylation of the intracellular guanylate triphosphate, and blocking the synthesis of viral nucleic acid.
2, ribavirin triphosphate can inhibit the influenza virus RNA polymerase and interfere with viral replication.
3, ribavirin triphosphate can inhibit the synthesis of viral mRNA 5 'end and transcriptase, thereby inhibiting the DNA and RNA synthesis. It has inhibitory effect on various kinds of viruses (including DNA viruses and RNA viruses). It also has prevention and treatment effect on the influenza, adenovirus pneumonia, hepatitis, herpes, and measles and is also effective on treating the epidemic hemorrhagic fever.
4, it is mainly excreted through urine in the prototype with also a small amount of de-sugarized ribavirin metabolites with a small amount discharged from the feces.
The above information is edited by the Chemicalbook of Dai Xiongfeng.
Chemical PropertiesThis product is colorless or white crystalline powder and is odorless with no taste. It is stable in room temperature. It is easily soluble in water and slightly soluble in ethanol, chloroform and ether. It has its mp being 174-176 ℃ or 160-167 ℃ (refined products include two crystals).
UsesIt is a kind of broad-spectrum antiviral drugs for treating influenza (influenza A and B viruses), adenovirus pneumonia, hepatitis, herpes, measles with prevention and treatment effect; it is also effective on treating the epidemic hemorrhagic fever, particularly effective treatment of patients in their early stages. Oral administration can cause diarrhea without other significant toxicity but may cause neutropenia. Large dose can inhibit the maturation of hemoglobin and red blood cells, causing reversible anemia. There have been reports regarding to the teratogenicity and embryo toxicity in animal experiments. Pregnant women should be hanged.
Ribavirin is a broad-spectrum antiviral nucleoside drug used for treating influenza, adenovirus pneumonia of children, viral hepatitis, respiratory syncytial virus infection, acute keratitis, conjunctivitis, epidemic hemorrhagic fever and herpes zoster.
Production methodTake nucleotide or nucleoside as the starting material
First hydrolyze the guanosine and guanylate upon the action of glacial acetic acid and acetic anhydride to generate ribose-1-phosphate, which is then subject to the catalysis of double-para-nitro phenol to have reaction with triazide amide to generate condensate with aminolysis to obtain the product.
Guanosine (or guanylate) [acetic anhydride, glacial acetic acid]→[hydrolysis] ribose-1-phosphate [bis-(p-nitrophenol)-phosphate]→[triazide carboxamide] condensates [aminolysis]→Ribavirin
Enzymatic synthesis
First hydrolyze the guanosine and guanosine acid under the action of pyrimidine nucleoside phosphorylase to form ribose-1-phosphate which then, under the action of purine nucleoside phosphorylase, has reaction with triazide amide to directly generate triazole nucleosides.
Guanosine (or guanylate) [pyrimidine nucleoside phosphorylase] → ribose-1 nucleic acid [purine nucleotide cyclase] → Ribavirin.
Chemical PropertiesColourless Solid
UsesPurine nucleoside analog; inhibits inosine monophosphate dehydrogenase (IMPDH). Used as an antiviral agent.
Usesaldosterone antagonist; antifibrogenic
Usesanti-infective, anti-fungal
UsesA broad spectrum antiviral nucleoside and inhibitor of inosine monophosphate dehydrogenase.
DefinitionChEBI: A 1-ribosyltriazole that is the 1-ribofuranosyl derivative of 1,2,4-triazole-3-carboxamide. An inhibitor of HCV polymerase.
UsesRibavirin is a guanosine analog with antiviral properties against DNA and RNA viruses, including respiratory syncytial virus, hepatitis C, and influenza. It acts as a prodrug that can be activated by either mono- or tri-phosphorylation by cellular kinases. These phosphorylated derivatives of ribavirin have diverse effects on both cellular and viral enzymes, resulting in suppression of viral replication.
Brand nameCopegus (Roche); Rebetol (Schering); Virazole (Valeant).
General DescriptionWhite powder. Exists in two polymorphic forms.
Air & Water ReactionsWater soluble.
Reactivity ProfileRibavirin may be sensitive to prolonged exposure to light.
HazardMildly toxic by ingestion. An experimental teratogen.
Fire HazardFlash point data for Ribavirin are not available; however, Ribavirin is probably combustible.
Tag:Ribavirin(36791-04-5) Related Product Information
RIBAVIRIN 5'-TRIPHOSPHATE, TETRAAMMONIUM SALT Ribavirin base ribavirin 5'-diphosphate 250 MG RIBAVIRIN RIBAVIRIN IMP. D (EP): 1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE Secnidazole,Ribavirin RIBAVIRIN VIRAZOLE = RBV ribavirin 3',5'-phosphate pentadecamer homoribopolymer Ribavirin FDA,CGMP,ISO,KOSHER Ribazid(Ribavirin) RIBAVIRIN 5'-TRIPHOSPHATE, TETRAAMMONIUM SALT, [3H]- RIBAVIRIN IMP. F (EP): 1-(5-O-ACETYL-B-D-RIBOFURANOSYL)-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE (5'-O-ACETYLRIBAVIRIN) TARIBAVIRIN RIBAVIRIN USP24 1-CHLOROMETHYL-1H-1,2,4-TRIAZOLE 1,2,4-Triazole 5-Methyl-1H-benzotriazole Ribavirin