| Identification | More | [Name]
Aminoacetonitrile hydrochloride | [CAS]
6011-14-9 | [Synonyms]
AMINO ACETONITRILE HCL
AMINOACETONITRILE HYDROCHLORIDE
Glycinonitrile hydrochloride
alpha-aminoacetonitrilehydrochloride
aminoacetonitrilemonohydrochloride
amino-acetonitrilmonohydrochloride
glycinonitrile,monohydrochloride
2-AminoacetonitrileHydrochloride
GlycinonitrileHCl
Aminoacetonitrilehydrochloride,97%
Acetonitrile, amino-, monohydrochloride
AMINOACETONITRILE A.K.A. GLYCINONITRILE HYDROCHLOR
Aminoacetonitrile hydrochloride, 98+%
Cyanomethylazanium chloride | [EINECS(EC#)]
227-865-9 | [Molecular Formula]
C2H5ClN2 | [MDL Number]
MFCD00012850 | [Molecular Weight]
92.53 | [MOL File]
6011-14-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
172-174°C | [RTECS ]
MC1950000 | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Methanol (Slightly, Heated), Water | [form ]
Powder | [color ]
White to Off-White | [Water Solubility ]
Soluble in water 20°C, 1000g/L. | [Sensitive ]
Hygroscopic | [Detection Methods]
NMR,T | [Merck ]
14,412 | [InChI]
InChI=1S/C2H4N2.ClH/c3-1-2-4;/h1,3H2;1H | [InChIKey]
XFKYKTBPRBZDFG-UHFFFAOYSA-N | [SMILES]
C(N)C#N.Cl | [CAS DataBase Reference]
6011-14-9(CAS DataBase Reference) | [Storage Precautions]
Moisture sensitive | [EPA Substance Registry System]
6011-14-9(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS06 | [Signal word ]
Danger | [Hazard statements ]
H301-H315-H319-H335 | [Precautionary statements ]
P280h-P305+P351+P338-P309-P310a | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S22:Do not breathe dust .
S36/37:Wear suitable protective clothing and gloves . | [RIDADR ]
3439 | [TSCA ]
Yes | [REACH Registrations]
Active | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29269090 | [Safety Profile]
An experimental
teratogen. Experimental reproductive
effects. When heated to decomposition it
emits toxic fumes of NOx and HCl. |
| Hazard Information | Back Directory | [Chemical Properties]
White to light brown solid | [Uses]
Used as pharmaceutical intermediates, organic synthetic raw material transportation. | [Application]
Aminoacetonitrile is a useful synthetic intermediate. It is a reagent used to synthesize dipeptide nitriles as reversible and potent cathepsin S inhibitors. It can also used to prepare substituted cyclic ureas as possible HIV protease inhibitors. | [Preparation]
Synthesis of Aminoacetonitrile Hydrochloride by Reaction of Aminoacetonitrile with Hydrogen Chloride in Methanol: mixing the aminoacetonitrile with hydrogen chloride methanol solution, reacting at 45-50°C for 1-2 hours, cooling to below 5°C, filtering, and centrifugalizing to obtain the aminoacetonitrile hydrochloride, wherein in the hydrogen chloride methanol solution, the content of hydrogen chloride is 30-50 wt%, and the water content is less than or equal to 1%.
Preparation method of aminoacetonitrile hydrochloride | [Purification Methods]
The salt recrystallises from dilute EtOH as hygroscopic leaflets. It is best to crystallise it from absolute EtOH/Et2O (1:1) and then recrystallise it from absolute EtOH. The melting point recorded ranges from 144o to 174o. The free base has b 58o/15mm with partial decomposition. [Klages J Prakt Chem [2] 65 189 1902, Mange J Am Chem Soc 56 2197 1934, Goldberg & Kelly J Chem Soc 1371 1947, Beilstein 4 H 344, 4 I 468, 4 II 783, 4 III 1120, 4 IV 2363.] |
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J & K SCIENTIFIC LTD.
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Alfa Aesar
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Energy Chemical
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Jia Xing Isenchem Co.,Ltd
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