| Identification | More | [Name]
2-CHLORO-6-NITROPHENOL | [CAS]
603-86-1 | [Synonyms]
1-CHLORO-2-HYDROXY-3-NITROBENZENE
2-CHLORO-6-NITROPHENOL
6-NITRO-O-CHLOROPHENOL
2-chloro-6-nitro-pheno
Phenol, 2-chloro-6-nitro-
2-NITRO-6-CHLOROPHENOL | [EINECS(EC#)]
210-061-7 | [Molecular Formula]
C6H4ClNO3 | [MDL Number]
MFCD00024233 | [Molecular Weight]
173.55 | [MOL File]
603-86-1.mol |
| Chemical Properties | Back Directory | [Appearance]
yellow crystalline powder | [Melting point ]
67-71 °C
| [Boiling point ]
217.3±20.0 °C(Predicted) | [density ]
1.4914 (rough estimate) | [refractive index ]
1.5810 (estimate) | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
Crystalline Powder | [pka]
5.43±0.24(Predicted) | [color ]
Yellow | [λmax]
405nm(lit.) | [InChI]
InChI=1S/C6H4ClNO3/c7-4-2-1-3-5(6(4)9)8(10)11/h1-3,9H | [InChIKey]
ICCYFVWQNFMENX-UHFFFAOYSA-N | [SMILES]
C1(O)=C([N+]([O-])=O)C=CC=C1Cl | [CAS DataBase Reference]
603-86-1(CAS DataBase Reference) | [EPA Substance Registry System]
Phenol, 2-chloro-6-nitro- (603-86-1) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302-H315-H319-H335 | [Precautionary statements ]
P261-P280a-P304+P340-P305+P351+P338-P405-P501a | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
2811 | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29089990 |
| Hazard Information | Back Directory | [Chemical Properties]
yellow crystalline powder | [Synthesis]
0.5mmol of 2-(2-chloro-6-nitrophenoxy)pyridine and 0.08ml of methyl trifluoromethanesulfonate were dissolved in 20ml of toluene and reacted at 100°C for 2 hours in a three-necked flask under nitrogen protection. The solvent was removed, 10mmol of sodium metal and 20ml of methanol were added, and the reaction was carried out at 80°C for 30min under nitrogen protection. After the reaction was completed by TLC detection, ethyl acetate was extracted, the extract was dried over anhydrous sodium sulfate, and the solvent was removed under reduced pressure. 2-chloro-6-nitrophenol (89% yield) was separated by column chromatography (eluent ratio: petroleum ether to ethyl acetate volume ratio 6:1).
| [References]
[1] Chinese Chemical Letters, 2010, vol. 21, # 4, p. 403 - 406
[2] Synthetic Communications, 2011, vol. 41, # 20, p. 2985 - 2992
[3] Journal of Medicinal Chemistry, 1996, vol. 39, # 18, p. 3435 - 3450
[4] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 15, p. 3521 - 3525
[5] Journal of the Chemical Society, 1927, p. 1692 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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