| Identification | More | [Name]
(S)-Oxiranemethanol | [CAS]
60456-23-7 | [Synonyms]
[(2r)-oxiran-2-yl]methanol
OXIRANEMETHANOL, (2S)-
(r)-3-hydroxy-1,2-epoxypropane
RARECHEM AK HZ 0047
(S)-(-)-2,3-EPOXY-1-PROPANOL
(S)-(-)-GLYCIDOL
(S)-GLYCIDOL
S(-)-OXIRANE-2-METHANOL
(S)-Oxiranemethanol
(s)-oxiranemethano
Oxiranemethanol,(S)-
(S)-(-)-GLYCIDOL, 97% (98% EE/GLC)
S-Glycidoe
(R)-3-Hydroxy-1,2-epoxypropane
(S)-(-)-GLYCIDOL ((S)-(-)-2,3-EPOXY-1-PROPANOL)
(S)-(-)-2,3-Epoxy-1-propanol, (S)-(-)-Oxirane-2-methanol | [Molecular Formula]
C3H6O2 | [MDL Number]
MFCD00074874 | [Molecular Weight]
74.08 | [MOL File]
60456-23-7.mol |
| Chemical Properties | Back Directory | [Appearance]
Colorless to light yellow liqui | [Melting point ]
72-73 °C | [alpha ]
-15 º (neat) | [Boiling point ]
66-67 °C19 mm Hg(lit.) | [density ]
1.116 g/mL at 20 °C(lit.)
| [refractive index ]
n20/D 1.433(lit.)
| [Fp ]
178 °F
| [storage temp. ]
−20°C
| [solubility ]
Soluble in chloroform, DMSO and methanol. | [form ]
Liquid | [pka]
14.62±0.10(Predicted) | [color ]
Pale yellow | [Optical Rotation]
[α]20/D 15°, neat | [BRN ]
79783 | [InChI]
1S/C3H6O2/c4-1-3-2-5-3/h3-4H,1-2H2/t3-/m0/s1 | [InChIKey]
CTKINSOISVBQLD-VKHMYHEASA-N | [SMILES]
OC[C@H]1CO1 | [CAS DataBase Reference]
60456-23-7(CAS DataBase Reference) | [NIST Chemistry Reference]
Oxiranemethanol, (S)-(60456-23-7) |
| Questions And Answer | Back Directory | [Synthesis]
To 1.2 L of dichloromethane, 200 g of (S)-3-chloro-1,2-propanediol (99.5% ee) and 419 g of potassium phosphate were added. The resulting mixture was refluxed with stirring for 3 hours. The solution was then cooled to room temperature and filtered to remove the insoluble solid precipitate. The dichloromethane was then evaporated under reduced pressure. The residue was purified by fractional distillation (66°C/19 mmHg) to obtain 122 g of the target compound: (S)-glycidol. Yield: 122 g, Chemical purity: 99.0%, Optical purity (GC): 99.5%.  Figure (S) - Synthetic route of (S)-Oxiranemethanol |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS06,GHS08 | [Signal word ]
Danger | [Hazard statements ]
H302+H312-H315-H319-H330-H335-H341-H350-H360F | [Precautionary statements ]
P202-P280-P301+P312-P302+P352+P312-P304+P340+P310-P305+P351+P338 | [Hazard Codes ]
T | [Risk Statements ]
R45:May cause cancer.
R60:May impair fertility.
R21/22:Harmful in contact with skin and if swallowed .
R23:Toxic by inhalation.
R36/37/38:Irritating to eyes, respiratory system and skin .
R68:Possible risk of irreversible effects.
R41:Risk of serious damage to eyes.
R37/38:Irritating to respiratory system and skin . | [Safety Statements ]
S53:Avoid exposure-obtain special instruction before use .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
UN 2810 6.1/PG 2
| [WGK Germany ]
3
| [RTECS ]
RR0508100
| [F ]
10-21 | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29109000 | [Storage Class]
6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | [Hazard Classifications]
Acute Tox. 2 Inhalation
Acute Tox. 4 Dermal
Acute Tox. 4 Oral
Carc. 1B
Eye Irrit. 2
Muta. 2
Repr. 1B
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless to light yellow liqui | [Uses]
Employed in the synthesis of chiral (E)-allylic alcohol side-chains for introduction into prostacyclin and prostaglandin frameworks by cross-metathesis. | [Definition]
ChEBI: (S)-glycidol is a glycidol. It is functionally related to a (S)-1,2-epoxypropane. It is an enantiomer of a (R)-glycidol. | [General Description]
Glycidol or 2,3-epoxy-1-propanol is a highly reactive epoxy derivative, which is generally used as a monomer in the preparation of many polymers like polyesters,?polycarbonates,?polyurethanes,?and polyamides. It is also used in the preparation of detergents, rubbers, perfumes, fabric dyes, varnishes, cosmetics, and paints. | [Purification Methods]
[S(-)-isomer, § also available on polymer support, has b 49-50o/7mm, 66-67o/19mm, [ ] D -1 5o(neat)], [R(+)-isomer has b 56 -5 6 . 5o/11mm, d 4 1.117, n D 1.429, [ ] D +15o (neat)]. Purify glycidol by fractional distillation. |
|
| Company Name: |
Changzhou Huaren Chemical Co., Ltd Gold
|
| Telephone: |
0519-88103998, 13646148298, 88103997, 88122965,88100916 13646148298;051988100916; |
| Website: |
http://www.huarenchem.com |
| Company Name: |
J & K SCIENTIFIC LTD.
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| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
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