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67-56-1

67-56-1 Structure

67-56-1 Structure
IdentificationMore
[Name]

Methanol
[CAS]

67-56-1
[Synonyms]

2-[4-(DIMETHYLAMINO)PHENYLAZO]BENZOIC ACID
4-DIMETHYLAMINOAZOBENZENE-2'-CARBOXYLIC ACID
4-DIMETHYLAMINOAZOBENZENE-2-CARBOXYLIC ACID
ACID RED
ACID RED 2
CI 13020
CI NO 13020
METHYL RED
METHYL RED ETHANOL
METHYL RED INDICATOR
METHYL RED MIXED SOLUTION
METHYL RED MIXED SOLUTION R
METHYL RED, NEUTRAL
METHYL RED SOLUTION R
METHYL RED, SPIRIT SOLUBLE
METHYL RED, WATER SOLUBLE
O-(P-DIMETHYLAMINOPHENYLAZO)BENZOIC ACID
P-DIMETHYLAMINOAZOBENZENE-O-CARBOXYLIC ACID
S NO 250
ai3-00409
[EINECS(EC#)]

200-659-6
[Molecular Formula]

CH4O
[MDL Number]

MFCD00002425
[Molecular Weight]

32.04
[MOL File]

67-56-1.mol
Chemical PropertiesBack Directory
[Appearance]

Clear, colourless, volatile, hygroscopic liquid.
[Appearance]

Colorless liquid
[Appearance]

Methyl alcohol is a colorless, volatile liquid with a mild odor.
[mp ]

-98 °C(lit.)
[bp ]

65.4 °C(lit.)
[density ]

0.791 g/mL at 25 °C
[vapor density ]

1.11 (vs air)
[vapor pressure ]

410 mm Hg ( 50 °C)
[refractive index ]

n20/D 1.329(lit.)
[Fp ]

52 °F
[storage temp. ]

Store at RT.
[color ]

<10(APHA)
[Water Solubility ]

miscible
[Merck ]

14,5957
[Detection Methods]

GC
[BRN ]

1098229
[CAS DataBase Reference]

67-56-1(CAS DataBase Reference)
[NIST Chemistry Reference]

Methyl alcohol(67-56-1)
[Storage Precautions]

Moisture sensitive
[EPA Substance Registry System]

67-56-1(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

Xn,T,F
[Risk Statements ]

R10:Flammable.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R68/20/21/22:Harmful: possible risk of irreversible effects through inhalation, in contact with skin and if swallowed .
R39/23/24/25:Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed .
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R11:Highly Flammable.
R40:Limited evidence of a carcinogenic effect.
R36:Irritating to the eyes.
R36/38:Irritating to eyes and skin .
R23/25:Toxic by inhalation and if swallowed .
[Safety Statements ]

S36/37:Wear suitable protective clothing and gloves .
S7:Keep container tightly closed .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S16:Keep away from sources of ignition-No smoking .
S24/25:Avoid contact with skin and eyes .
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S24:Avoid contact with skin .
[RIDADR ]

UN 1170 3/PG 2
[WGK Germany ]

1
[RTECS ]

PC1400000
[F ]

3-10
[HazardClass ]

3
[PackingGroup ]

II
[HS Code ]

29051100
[Safety Profile]

A human poison by ingestion. Poison experimentally by skin contact. Moderately toxic experimentally by intravenous and intraperitoneal routes. Mildly toxic by inhalation. Human systemic effects: changes in circulation, cough, dyspnea, headache, lachrymation, nausea or vomiting, optic nerve neuropathy, respiratory effects, visual field changes. An experimental teratogen. Experimental reproductive effects. An eye and skin irritant. Human mutation data reported. A narcotic. Its main toxic effect is exerted upon the nervous system, particularly the optic nerves and possibly the retinae. The condtion can progress to permanent blindness. Once absorbed, methanol is only very slowly eliminated. Coma resulting from massive exposures may last as long as 2-4 days. In the body, the products formed by its oxidation are formaldehyde and formic acid, both of which are toxic. Because of the slow elimination, methanol should be regarded as a cumulative poison. Though single exposures to fumes may cause no harmful effect, daily exposure may result in the accumulation of sufficient methanol in the body to cause illness. Death from ingestion of less than 30 mL has been reported. A common air contaminant. Flammable liquid. Dangerous fire hazard when exposed to heat, flame, or oxidlzers. Explosive in the form of vapor when exposed to heat or flame. Explosive reaction with chloroform + sodium methoxide, diethyl zinc. Violent reaction with alkyl aluminum salts, acetyl bromide, chloroform + sodlum hydroxide, CrO3, cyanuric chloride, (I + ethanol + HgO), Pb(ClO4)2, HClO4, P2O3, (KOH + CHCb), nitric acid. Incompatible with berylhum dihydride, metals (e.g., potassium, magnesium), oxidants (e.g., barium perchlorate, bromine, sodium hypochlorite, chlorine, hydrogen peroxide), potassium tert-butoxide, carbon tetrachloride + metals (e.g., aluminum, magnesium, zinc), dlchloromethane. Dangerous; can react vigorously with oxidizing materials. To fight fire, use alcohol foam. When heated to decomposition it emits acrid smoke and irritating fumes.
[Hazardous Substances Data]

67-56-1(Hazardous Substances Data)
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Sodium hydroxide-->Hydrogen-->CARBON DIOXIDE-->Oxygen-->CARBON MONOXIDE-->tert-Butyl methyl ether-->Lactic acid -->METALLURGICAL COKE--> HEAVY CUT RESIDUE OIL-->METHANE-->2 DIESEL FUEL-->Residuum-->L(+)-Lactic acid
[Preparation Products]

H-DL-PRO-OME HCL-->2-Amino-4-methoxypyridine-->1,5-NAPHTHALENEDISULFONIC ACID DISODIUM SALT, DIHYDRATE, 98-->3,5-Dimethoxybenzyl alcohol-->METHYL 3-AMINOBENZOATE-->3-Methacryloxypropyltrimethoxysilane-->3'-DIMETHYLAMINOACETOPHENONE-->5-METHYL-2-HEXANOL-->TETRAHYDRO-3-FUROIC ACID-->2-Quinolinemethanamine-->NICOTINIC ACID HYDRAZIDE-->5-Bromo-4,6-dihydroxypyrimidine-->1-(1,3-DIHYDRO-1-OXOISOBENZOFURAN-3-YL)UREA-->(1H-IMIDAZOL-2-YL)-METHANOL-->2-OXO-6-PHENYL-4-(TRIFLUOROMETHYL)-1,2-DIHYDRO-3-PYRIDINECARBONITRILE-->Ethyl 3-(benzylamino)propanoate-->METHYL TRICOSANOATE-->5-BROMO-2-CHLORO-4-METHOXYPYRIMIDINE-->Methyl 4-aminobutyrate hydrochloride-->N,N'-BISBENZYLIDENEBENZIDINE-->4-Hydroxy-5-fluorpyrimidine-->TRIETHYLENE GLYCOL MONOMETHYL ETHER-->1-Chloropinacolone-->Dipropylene glycol monomethyl ether-->3-(METHOXYCARBONYL)PYRIDINE-2-CARBOXYLIC ACID-->4-(METHOXYCARBONYL)NICOTINIC ACID-->Methyl 3,4-dimethylbenzoate-->4-Bromobenzyl alcohol-->4-MORPHOLINECARBOXAMIDINE-->2-Thiophenecarboxylic acid hydrazide-->METHYL HYDROGEN GLUTARATE-->METHYL STEARATE-->2-Methoxy-3-isobutyl pyrazine-->Diphenyldimethoxysilane-->methylated albumin-->FEMA 2062-->3-Chloropropyltrimethoxysilane-->3-Glycidoxypropyltrimethoxysilane-->Vinyltrimethoxysilane-->Potassium methoxide
Hazard InformationBack Directory
[General Description]

A colorless fairly volatile liquid with a faintly sweet pungent odor like that of ethyl alcohol. Completely mixes with water. The vapors are slightly heavier than air and may travel some distance to a source of ignition and flash back. Any accumulation of vapors in confined spaces, such as buildings or sewers, may explode if ignited. Used to make chemicals, to remove water from automotive and aviation fuels, as a solvent for paints and plastics, and as an ingredient in a wide variety of products.
[Reactivity Profile]

METHANOL(67-56-1) reacts violently with acetyl bromide [Merck 11th ed. 1989]. Mixtures with concentrated sulfuric acid and concentrated hydrogen peroxide can cause explosions. Reacts with hypochlorous acid either in water solution or mixed water/carbon tetrachloride solution to give methyl hypochlorite, which decomposes in the cold and may explode on exposure to sunlight or heat. Gives the same product with chlorine. Can react explosively with isocyanates under basic conditions. The presence of an inert solvent mitigates this reaction [Wischmeyer 1969]. A violent exothermic reaction occurred between methyl alcohol and bromine in a mixing cylinder [MCA Case History 1863. 1972]. A flask of anhydrous lead perchlorate dissolved in METHANOL(67-56-1) exploded when METHANOL(67-56-1) was disturbed [J. Am. Chem. Soc. 52:2391. 1930]. P4O6 reacts violently with METHANOL(67-56-1). (Thorpe, T. E. et al., J. Chem. Soc., 1890, 57, 569-573). Ethanol or METHANOL(67-56-1) can ignite on contact with a platinum-black catalyst. (Urben 1794).
[Air & Water Reactions]

Highly flammable. Soluble in water in all proportions.
[Hazard]

Flammable, dangerous fire risk. Explosive limits in air 6–36.5% by volume. Toxic by ingestion (causes blindness). Headache, eye damage, dizziness, and nausea.
[Health Hazard]

Exposure to excessive vapor causes eye irritation, head-ache, fatigue and drowsiness. High concentrations can produce central nervous system depression and optic nerve damage. 50,000 ppm will probably cause death in 1 to 2 hrs. Can be absorbed through skin. Swallowing may cause death or eye damage.
[Fire Hazard]

Behavior in Fire: Containers may explode.
[First aid]

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.
[Shipping]

UN1230 Methanol, Hazard Class: 3; Labels: 3-Flammable liquid, 6.1-Poisonous material. (International)
[Incompatibilities]

Methanol reacts violently with strong oxidizers, causing a fire and explosion hazard.
[Waste Disposal]

Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal. Incineration
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

Carbinol(67-56-1).msds
Questions And AnswerBack Directory
[Introduction]

Methanol is the simplest fatty alcohol. It is a colorless, flammable, irritating liquid with a boiling point of 64.7°C, a melting point of -93.90°C, and a relative density of 0.7913. Soluble in water and most organic solvents. Its severe toxicity can damage the optic nerve. Once swallowed, it can make the eyes blind and even cause death.
Methanol has the general properties of a primary aliphatic alcohol. The three hydrogen atoms on a carbon atom with a hydroxyl group can be oxidized, orderly generating formaldehyde, formic acid, and carbon dioxide. Therefore, it is largely used in the synthesis of formaldehyde. Methanol is easily converted into important organic synthesis intermediates such as methyl carboxylate, methyl chloride and methylamine, and it is also applied as important organic solvents, extraction agents and alcohol denaturants.
[Uses]

Methanol is an important chemical raw material for fine chemicals. Its carbonylation at 3.5 MPa and 180-200° C in the presence of catalyst can produce acetic acid and further produce acetic anhydride. It reacts with syngas to prepare vinyl acetate in the presence of catalyst; reacts with isobutylene to produce tert-butyl methyl ether; prepare dimethyl oxalate through oxidization and carbonylation, and a further hydrogenation to produce ethylene glycol; reacts with toluene under catalyst and simultaneous oxidization to produce phenylethyl alcohol. It can be used as a good solvent, as a pesticide raw material, as an antifreeze agent, as a fuel and fuel additive (this is receiving increasing attention in environmental protection field). It is the main raw material in the preparation of formaldehyde, the raw material in medicine and spices production, a solvent in dyes and paint industries, the raw material in preparation of methanol single cell protein and synthesis of methyl ester.
Industry Applications Role/Benefit
Laboratory HPLC, UV/VIS spectroscopy, and LCMS Low UV cutoff
Chemical manufacture Production of formaldehyde and its derivates Main feedstock
Production of hydrocarbon chains and even aromatic systems Main feedstock
Production of methyl tert-butyl ether Methylation reagent
Production of dimethyl terephthalic acid, methyl methacrylate and acrylic acid methyl ester Main feedstock
Plastics Production of polymers Main feedstock
Farm chemical Production of insecticide and acaricide Main feedstock
Pharmaceuticals Production of sulfonamides, amycin, etc Main feedstock
Fuel for vehicles Pure methanol fuel Pure methanol does not produce an opaque cloud of smoke in the event of an accident
Methanol gasoline Blended directly into gasoline to produce a high-octane, efficient fuel with lower emissions than conventional gasoline
Chemical analysis Determination of boron Analysis agent
Determination of trace moisture in alcohols, saturated hydrocarbons, benzene, chloroform, pyridine Analysis agent
Others Separation of calcium sulfate and magnesium sulfate Separation reagent
Separation of strontium bromide and barium bromide Separation reagent
Anti-freezing agent Effective component
[Reactivities of Methanol]

Methanol is the simplest aliphatic alcohol. It contains only one carbon atom. Unlike higher alcohols, it cannot form an olefin through dehydration. However, it can undergo other typical reactions of aliphatic alcohols involving cleavage of a C-H bond or O-H bond and displacement of the -OH group. Table 1 summarizes the reactions of methanol, which are classified in terms of their mechanisms. Examples of the reactions and products are given.

Homolytic dissociation energies of the C-O and O-H bonds in methanol are relatively high. Catalysts are often used to activate the bonds and to increase the selectivity to desired products.
[Methanol poisoning and First Aid Measures]

Pathogenesis
First, methanol has a cumulative effect and is oxidized in the body into more toxic formaldehyde and formic acid. Methanol and its oxides directly damage the tissues, causing cerebral edema, meningeal hemorrhage, optic nerve and retinal atrophy, pulmonary congestion and edema, and hepatic and renal turbid swelling.
Second, methanol and its oxides cause blood circulation disorder, coenzyme system obstacles in vivo, resulting in lack of oxygen supply to the brain cortical cells, metabolic disorders, and related neurological and psychiatric symptoms.
Third, methanol oxidation products combine with the iron in the cytochrome oxidase, which inhibits the intracellular oxidation process thus causing metabolic disorders, acidosis along with organic acid accumulation in the body, and nerve cells impair.

Treatment
  • Keep away from the methanol dispersion area, excrete methanol from the body.
    Antidote: Ethanol is an antidote to methanol poisoning. Ethanol can prevent methanol’s oxidation and promote its emission. Prepare 5% ethanol solution using 10% glucose solution, and drip slowly intravenously.
  • Maintain electrolyte balance: maintain respiratory and circulatory function, provide with a large number of Vitamin B.
    Treatment of acidosis: Administrate timely sodium bicarbonate solution or sodium lactate solution based on blood gas analysis, carbon dioxide binding force measurement and clinical performance.
  • Prevent cerebral edemas actively, reduce intracranial pressure, improve fundus blood circulation, and prevent optic neuropathy if needed.
  • Inject intravenously cytochrome C, polar fluid to restore cytochrome oxidase function.
  • Control mental state by applying diazepam, perphenazine and the like.
Symptoms and treatments:
Acute pain morphine, pethidine
Convulsions phenobarbital, amimystrine, diazepam
Coma caffeine sodium benzoate
Respiratory failure nikethamide, theophylline
[Production]

  • Methanol is prepared by pressure heating with carbon monoxide and hydrogen in the presence of a catalyst:
   
If the conditions are strictly controlled, the yield can reach 100% and the purity can reach 99%.
  • Methane is mixed with oxygen (9:1, V/V) and methanol is obtained through a copper tube under heating and pressure:
[Toxicity]

ADI is limited to GMP (FAO/WHO, 2001).
Toxic, can cause blindness.
LD50: 5628 mg/kg (rat, oral).
 
Measurement Date System Route/Organism Dose Effect
Skin and Eye Irritation December 2016   eye /rabbit 40 mg moderate
Skin and Eye Irritation December 2016   eye /rabbit 100 mg/24H moderate
Skin and Eye Irritation December 2016   skin /rabbit 20 mg/24H moderate
Mutation Data December 2016 Cytogenetic Analysis parenteral/grasshopper 3000 ppm  
Mutation Data December 2016 Cytogenetic Analysis oral/mouse 1 gm/kg  
Mutation Data December 2016 Cytogenetic Analysis intraperitoneal/mouse 75 mg/kg  
Mutation Data December 2016 DNA Damage oral/rat 10 µmol/kg  
Mutation Data December 2016 DNA inhibition lymphocyte/human 300 mmol/L  
Mutation Data December 2016 DNA repair /Escherichia coli 20 mg/well  
Mutation Data December 2016 morphological transform fibroblast/mouse 0.01 mg/L/21D (-enzymatic activation step)  
from The National Institute for Occupational Safety and Health - NIOSH
[Methanol gasoline]

Methanol gasoline refers to the M series mixture fuel made of addition of methanol to the gasoline and formulated using methanol fuel solvent. Among them, M15 (add 15% methanol in gasoline) clean methanol gasoline is used as vehicle fuel, respectively, used in a variety of gasoline engines. It can be applied to substitute the finished gasoline without changing the existing engine structure, and can also be mixed with refined oil. The methanol mixed fuel has excellent thermal efficiency, power, start-up and being economical. It is also characterized by lowering the emissions, saving oil and being safe and convenient. Methanol gasoline types of M35, M15, M20, M50, N85 and M100 with different blend ratios have been developed around the world according to the conditions of different countries. At present, the commercial methanol is mainly M85 (85% methanol + 15% gasoline) and M100 with M100 performance being better than M85 and having greater environmental advantages.
Spectrum DetailBack Directory
[Spectrum Detail]

Methanol(67-56-1)13CNMR
Methanol(67-56-1)1HNMR
Methanol(67-56-1)IR1
Methanol(67-56-1)Raman
Methanol(67-56-1)ESR
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

Methanol, AcroSeal?, Extra Dry over Molecular Sieve, 99.8%(67-56-1)
[Alfa Aesar]

Methanol, ultrapure, Spectrophotometric Grade, 99.8+%(67-56-1)
[Sigma Aldrich]

67-56-1(sigmaaldrich)
[TCI AMERICA]

Methanol,>99.8%(GC)(67-56-1)
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