| Hazard Information | Back Directory | [Uses]
SUN 1334H is a potent, orally active, highly selective H1 receptor antagonist, with Ki of 9.7 nM. | [in vivo]
SUN-1334H potently inhibits histamine-induced bronchospasm over 24 hours following oral administration and completely suppresses histamine-induced skin wheal in beagle dogs and ovalbumin-induced rhinitis in guinea pigs[1]. In skin allergy models, SUN-1334H shows potent reduction of passive and active cutaneous anaphylactic reactions. In central nervous system side effects models, SUN-1334H, desloratadine and fexofenadine are devoid of any significant effects[2]. | [IC 50]
H1 Receptor | [storage]
Store at -20°C | [References]
[1] Mandhane SN, et al. Preclinical efficacy and safety pharmacology of SUN-1334H, a potent orally active antihistamine agent. Drugs R D. 2008;9(2):93-112. DOI:10.2165/00126839-200809020-00004
[2] Mandhane SN, et al. Characterization of anti-inflammatory properties and evidence for no sedation liability for the novel antihistamine SUN-1334H. Int Arch Allergy Immunol. 2010;151(1):56-69. DOI:10.1159/000232571 |
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