| Chemical Properties | Back Directory | [Melting point ]
167-169 °C(Solv: ethanol (64-17-5); water (7732-18-5)) | [storage temp. ]
4°C, away from moisture | [solubility ]
DMSO : 120 mg/mL (257.70 mM) | [form ]
Solid | [color ]
Off-white to gray |
| Hazard Information | Back Directory | [Uses]
Pactimibe Sulfate (2:1) is an impurity of Pactimibe(189198-30-9) and can be used to prepare oral pharmaceuticals microspheres. | [in vivo]
Pactimibe sulfate (CS-505; 60 and 200 mg/kg/day; oral gavage; twice a day; 12 weeks) induces an inhibition for ACAT-1 and ACAT-2, causing a reduction of plasma cholesterol but no influence on macrophage- or collagen-positive areas[3]. | Animal Model: | Male C57BL/6J ApoE?/? mice aged 8-week-old[3] | | Dosage: | 60 and 200 mg/kg/day | | Administration: | Oral gavage; twice a day; 12 weeks | | Result: | Decreased plasma cholesterol levels by 39% and 74% at the administration of 60 and 200 mg/kg/day. |
| [IC 50]
ACAT1: 4.9 μM (IC50); ACAT2: 3.0 μM (IC50); ACAT: 2 μM (IC50, in the liver); ACAT: 2.7 μM (IC50, in macrophages); ACAT: 4.7 μM (IC50, in THP-1 cells); oleoyl-CoA: 5.6 μM (Ki); cholesteryl ester formation: 6.7 μM (IC50) |
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