| Identification | Back Directory | [Name]
(3-HYDROXY-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER | [CAS]
610302-03-9 | [Synonyms]
3-(Boc-aMino)cyclohexanol
3-N-BOC-AMINO-CYCLOHEXANOL
1-N-Boc aminocyclohexan-3-ol
TERT-BUTYL 3-HYDROXYCYCLOHEXYL CARBAMATE
5-amino-2-methylpyridine-3-carboxylic acid
tert-butyl N-(3-hydroxycyclohexyl)carbaMate
cis-1-N-Boc-3-hydroxy-cyclohexylamine(racemic)
1,1-DiMethylethyl (3-hydroxycyclohexyl)carbaMate
trans-1-N-Boc-3-hydroxy-cyclohexylamine
(racemic)
(3-HYDROXY-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER
(3-Hydroxy-cyclohexyl)-carbamic acid tert-butyl ester, >=97%
Carbamic acid,N-(3-hydroxycyclohexyl)-, 1,1-dimethylethyl ester
Carbamic acid, (3-hydroxycyclohexyl)-, 1,1-dimethylethyl ester (9CI) | [Molecular Formula]
C11H21NO3 | [MDL Number]
MFCD06658389 | [MOL File]
610302-03-9.mol | [Molecular Weight]
215.29 |
| Chemical Properties | Back Directory | [Boiling point ]
337.7±31.0 °C(Predicted) | [density ]
1.06 | [storage temp. ]
2-8°C | [pka]
12.32±0.40(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of tert-butyl 3-hydroxycyclohexylcarbamate from N-Boc-3-cyclohexanone amine was as follows: sodium borohydride (710 mg, 18.8 mmol, 2.0 eq.) was slowly added to a solution of tert-butyl 3-oxocyclohexylcarbamate (2.0 g, 9.38 mmol, 1.0 eq.) dissolved in methanol (20 mL) at 0 °C. The reaction mixture was stirred continuously for 14 hours at room temperature. Upon completion of the reaction, the reaction was quenched with deionized water (20 mL) followed by extraction with ethyl acetate (30 mL x 3). The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure to afford the target product tert-butyl 3-hydroxycyclohexylcarbamate (2.0 g, yield: 100%). | [References]
[1] Patent: US2016/200730, 2016, A1. Location in patent: Paragraph 0484; 0485
[2] Patent: WO2015/39348, 2015, A1. Location in patent: Page/Page column 34 |
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