| Identification | More | [Name]
5-Amino-2-methylpyridine | [CAS]
3430-14-6 | [Synonyms]
2-METHYL-5-AMINOPYRIDINE
3-AMINO-6-METHYLPYRIDINE
3-AMINO-6-PICOLINE
5-AMINO-2-METHYLPYRIDINE
5-AMINO-2-PICOLINE
6-METHYL-PYRIDIN-3-YLAMINE
AURORA KA-7923
6-Methyl-3-aminopyridine
2-Methyl-5-Aminoyridine
6-Methyl-Pyridin-3-yl
6-Methylpyridine-3-Amine
3-Pyridinamine,6-methyl-(9CI)
3-Pyridinamine, 6-methyl-
2-METHYL-5-AMINOPYRIDINE/3-AMINO-6-PICOLINE
5-AMINO-2-METHYLPYRIDINE (5-AMINO-2-PICOLINE)
5-amino-2-methylpyridine UNDER RD
6-Methylpyridin-3-amine
5-Amino-2-methylpyridine ,98% | [EINECS(EC#)]
625-232-5 | [Molecular Formula]
C6H8N2 | [MDL Number]
MFCD00833389 | [Molecular Weight]
108.14 | [MOL File]
3430-14-6.mol |
| Chemical Properties | Back Directory | [Melting point ]
95-99°C | [Boiling point ]
238.4±20.0 °C(Predicted) | [density ]
1.068±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
Powder | [pka]
6.89±0.10(Predicted) | [color ]
Off-white to orange to brown | [Detection Methods]
HPLC | [InChI]
InChI=1S/C6H8N2/c1-5-2-3-6(7)4-8-5/h2-4H,7H2,1H3 | [InChIKey]
UENBBJXGCWILBM-UHFFFAOYSA-N | [SMILES]
C1=NC(C)=CC=C1N | [LogP]
0.704 | [CAS DataBase Reference]
3430-14-6(CAS DataBase Reference) | [Storage Precautions]
Store under nitrogen |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS05,GHS07 | [Signal word ]
Danger | [Hazard statements ]
H302-H315-H318-H335 | [Precautionary statements ]
P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 | [Hazard Codes ]
Xn,Xi,C | [Risk Statements ]
R22:Harmful if swallowed.
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes.
R36/37/38:Irritating to eyes, respiratory system and skin .
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/39:Wear suitable protective clothing and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S36:Wear suitable protective clothing .
S27:Take off immediately all contaminated clothing . | [RIDADR ]
UN2811 | [WGK Germany ]
3 | [Hazard Note ]
Harmful | [REACH Registrations]
Active | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29333990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
White to orange to brown solid | [Uses]
6-Methylpyridine-3-amine, is a heterocyclic building block used in the manufacture of various pharmaceutical compounds. It can be used for the synthesis of 2-aminoquinazoline derivatives, as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators (mGluR5), leading toward a drug candidate for the treatment of l-DOPA induced dyskinesia. | [General Description]
5-Amino-2-methylpyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | [Synthesis]
To a 250 mL autoclave was added 100 mL of methanol (MeOH), 2-methyl-5-nitropyridine (15 g, 0.19 mol, 1.0 eq.) and 10% palladium/carbon catalyst (0.5 g, 3.3 wt%). The reaction mixture was stirred at room temperature for 18 h under 4 atm hydrogen pressure. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ratio of petroleum ether:ethyl acetate = 3:1) to confirm the completion of the reaction. Upon completion of the reaction, the reaction mixture was filtered to remove the catalyst. The filtrate was concentrated under reduced pressure to afford 3-amino-6-methylpyridine (11.5 g, HPLC purity: 97%) as a dark red solid in 98.3% yield. | [References]
[1] Patent: WO2018/208630, 2018, A1. Location in patent: Page/Page column 55
[2] Patent: US5580872, 1996, A
[3] Patent: US5733912, 1998, A
[4] Chemische Berichte, 1939, vol. 72, p. 577,579
[5] Journal of Medicinal Chemistry, 2003, vol. 46, # 22, p. 4676 - 4686 |
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