| Identification | More | [Name]
N-DESMETHYLCLOZAPINE | [CAS]
6104-71-8 | [Synonyms]
NORCLOZAPINE
Desmethylclozapine
Normethylclozapine
N-DESMETHYLCLOZAPINE
Norclozapine (ACP-104)
Clozapine EP IMpurity C
N-Desmethylclozapine solution
Norclozapine Solution, 100ppm
Desmethylclozapine (Norclozapine)
8-Chloro-11-(piperazin-1-yl)-5H-dib
N-Desmethyl Clozapine-d8 hydrochloride
Clozapine Impurity 3(Clozapine EP Impurity C)
Clozapine EP Impurity C (N-Desmethyl Clozapine)
NORCLOZAPINE; DESMETHYLCLOZAPINE; NORMETHYLCLOZAPINE
8-CHLORO-11-PIPERAZINYL-5H-DIBENZO[B,E][1,4]DIAZEPINE
3-chloro-6-piperazin-1-yl-5H-benzo[b][1,4]benzodiazepine
8-CHLORO-11-(1-PIPERAZINYL)-5H-DIBENZO[B,E][1,4]DIAZEPINE
8-CHLORO-11-1[1-PIPERAZINYL)-5H-DIBENZO[B,E][1,4]DIAZEPINE
8-Chloro-11-(piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
5H-Dibenzo[b,e][1,4]diazepine, 8-chloro-11-(1-piperazinyl)-
CLOZAPINE, NORMETHYL(NORMETHYLCLOZAPINE, NOR-CLOZAPINE, DESMETHYLC
8-Chloro-11-piperazinyl-5H-dibenzo[b,e][1,4]diazepine, Norclozapine, Normethylclozapine
Clozapine impurity 3/Clozapine EP Impurity C/Clozapine impurity A (USP)/8-chloro-11-(piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
Clozapine EP Impurity CQ: What is
Clozapine EP Impurity C Q: What is the CAS Number of
Clozapine EP Impurity C Q: What is the storage condition of
Clozapine EP Impurity C Q: What are the applications of
Clozapine EP Impurity C | [EINECS(EC#)]
636-421-7 | [Molecular Formula]
C17H17ClN4 | [MDL Number]
MFCD00210189 | [Molecular Weight]
312.8 | [MOL File]
6104-71-8.mol |
| Chemical Properties | Back Directory | [Appearance]
Yellow Crystalline Solid | [Melting point ]
120-125°C | [Boiling point ]
502.6±60.0 °C(Predicted) | [density ]
1.38±0.1 g/cm3(Predicted) | [Fp ]
9℃ | [storage temp. ]
Store at RT | [solubility ]
Chloroform (Slightly), DMSO, Methanol (Slightly) | [form ]
Yellow solid. | [pka]
8.49±0.10(Predicted) | [color ]
Light Yellow to Yellow | [Usage]
A major metabolite of Clozapine. A potent and selective 5-HT2C serotonin receptor antogonist. | [InChI]
1S/C17H17ClN4/c18-12-5-6-15-16(11-12)21-17(22-9-7-19-8-10-22)13-3-1-2-4-14(13)20-15/h1-6,11,19-20H,7-10H2 | [InChIKey]
JNNOSTQEZICQQP-UHFFFAOYSA-N | [SMILES]
Clc1ccc2Nc3ccccc3C(=Nc2c1)N4CCNCC4 | [CAS DataBase Reference]
6104-71-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R20/22:Harmful by inhalation and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S22:Do not breathe dust .
S36:Wear suitable protective clothing .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
3249 | [WGK Germany ]
3
| [HazardClass ]
6.1(b) | [PackingGroup ]
III | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Crystalline Solid | [Uses]
N-Desmethylclozapine has been used as standard to quantify the clozapine plasma levels in treatment-refractory Chinese schizophrenic patients. | [Uses]
A major metabolite of Clozapine (C587500). A potent and selective 5-HT2C serotonin receptor antogonist. | [Uses]
A major metabolite of Clozapine. A potent and selective 5-HT2C serotonin receptor antogonist. | [Definition]
ChEBI: A dibenzodoazepine substituted with chloro and piperazino groups which is a major metabolite of clozapine; a potent and selective 5-HT2C serotonin receptor antagonist. | [General Description]
N-Desmethylclozapine is an active metabolite of Clozapine, an atypical antipsychotic drug used for treatment of schizophrenia. Clozapine is sold under the trade names Clozaril? and FrazaClo in the US. This Certified Snap-N-Spike? Solution is suitable for use in urine drug testing, clinical toxicology, forensic analysis, and clinical monitoring by LC-MS/MS or GC/MS. | [Biological Activity]
A major metabolite of clozapine; a potent and selective 5-HT 2C serotonin receptor antagonist. | [Biochem/physiol Actions]
N-Desmethylclozapine serves as an agonist to muscarinic acetylcholine receptors, and is known to exert its antipsychotic action. It blocks synaptic transmission by antagonizing synaptic GABA (γ-aminobutyric acid) receptors. | [storage]
Room temperature |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
|