| Identification | More | [Name]
2-Methylbenzimidazole | [CAS]
615-15-6 | [Synonyms]
2-METHYL-1H-BENZIMIDAZOLE
2-METHYL-1H-BENZO[D]IMIDAZOLE
2-METHYLBENZIMIDAZOLE
AKOS 90363
RARECHEM AQ NN 0067
1H-2-Methylbenzimidazol
1H-2-Methylbenzimidazole
2-methyl-1h-benzimidazol
2-methyl-benzimidazol
Acetamidine, N-N'-o-phenylene-
Benzimidazole, 2-methyl-
Methyl-2-benzimidazole
n-n’-o-phenylene-acetamidin
2-METHYLENZIMIDAZOLE
2-Methylbenzimidazole,98%
1H-Benzimidazole, 2-methyl-
1H-Benzimidazole,2-methyl-(9CI)
2-Methyl-1,3-benzodiazde | [EINECS(EC#)]
210-411-9 | [Molecular Formula]
C8H8N2 | [MDL Number]
MFCD00005598 | [Molecular Weight]
132.16 | [MOL File]
615-15-6.mol |
| Chemical Properties | Back Directory | [Appearance]
light beige to brown crystalline powder | [Melting point ]
175-177 °C (lit.) | [Boiling point ]
234.08°C (rough estimate) | [density ]
1.1083 (rough estimate) | [refractive index ]
1.6013 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Crystalline Powder | [pka]
6.19(at 25℃) | [color ]
Light beige to brown | [Water Solubility ]
slightly soluble | [Detection Methods]
HPLC,NMR | [BRN ]
112264 | [InChI]
1S/C8H8N2/c1-6-9-7-4-2-3-5-8(7)10-6/h2-5H,1H3,(H,9,10) | [InChIKey]
LDZYRENCLPUXAX-UHFFFAOYSA-N | [SMILES]
Cc1nc2ccccc2[nH]1 | [CAS DataBase Reference]
615-15-6(CAS DataBase Reference) | [NIST Chemistry Reference]
1H-benzimidazole, 2-methyl-(615-15-6) | [EPA Substance Registry System]
615-15-6(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS05,GHS07 | [Signal word ]
Danger | [Hazard statements ]
H302-H315-H318-H335 | [Precautionary statements ]
P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S39:Wear eye/face protection . | [WGK Germany ]
3
| [RTECS ]
DD9100000
| [TSCA ]
Yes | [HS Code ]
29339990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 | [Safety Profile]
Poison by intravenous
route. Moderately toxic by ingestion.
Experimental reproductive effects. Mutation
data reported. When heated to
decomposition it emits toxic fumes of NOx. |
| Hazard Information | Back Directory | [Chemical Properties]
light beige to brown crystalline powder | [Uses]
- 2-Methylbenzimidazole is an important pharmacophore widely used in medicinal chemistry for the synthesis of various antibacterial and antifungal agents.
- It can be used as a key precursor to synthesize substituted benzimidazo[1,2-a]quinolones.
- It can be used in the synthesis of reversible solid-to-liquid phase transition coordination polymer crystals.
- 2-Methylbenzimidazole also exhibits corrosion inhibition.
| [Definition]
ChEBI: 2-Methyl-1H-benzo[d]imidazole is a member of benzimidazoles. | [Preparation]
2-Methylbenzimidazole is synthesized by the condensation of o-phenylenediamine with acetic acid. The mixture of o-phenylenediamine and acetic acid is heated at 100°C for 2 hours and then cooled slowly. 10% sodium hydroxide solution is added slowly to the mixture until it is slightly alkaline. The mixture is filtered and washed with cold water. The crude product is then recrystallized with water and decolorized with activated charcoal to obtain the final product. The yield is 68%. | [Synthesis Reference(s)]
Journal of Heterocyclic Chemistry, 26, p. 1163, 1989 DOI: 10.1002/jhet.5570260447
Chemical and Pharmaceutical Bulletin, 17, p. 1153, 1969 DOI: 10.1248/cpb.17.1153 | [Synthesis]
o-phenylenediamine and glacial acetic acid as raw materials undergo a condensation reaction in the presence of toluene as a solvent under the conditions of heating reflux to produce 2-methylbenzimidazole. The specific procedure is as follows: Add o-phenylenediamine and acetic acid to toluene, stir thoroughly, reflux for 2 to 12 hours, then cool directly and slowly to 0–30°C for crystallisation. Stir the crystallisation mixture for 0.5 to 12 hours, then pump and filter. Wash the solid with toluene, recover the toluene, and dry under reduced pressure to obtain the white solid powder 2-methylbenzimidazole.
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
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| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|