| Identification | Back Directory | [Name]
Triciribine | [CAS]
61966-08-3 | [Synonyms]
TCN-P
PTX200
PTX-200
VQD 002
PTX 200
NSC-280594
VQD-002 (TCN-P)
Tricirbine Phosphate
triciribine phosphate
Triciribine 5'-phosphate
URLYINUFLXOMHP-HTVVRFAVSA-N
Triciribine 13CD3 phosphate
Tricyclic Nucleoside Phosphate
Triciribine phosphate (NSC-280594)
1-(5-O-Phosphono-β-D-ribofuranosyl)-5-methyl-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylene-3-amine
1,5-Dihydro-5-methyl-1-(5-O-phosphono-β-D-ribofuranosyl)-1,4,5,6,8-pentaazaacenaphthylene-3-amine
1,4,5,6,8-Pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-(5-O-phosphono-β-D-ribofuranosyl)-
1,4,5,6,8-Pentaazaacenaphthylene-3-amino-1,5-dihydro-5-methyl-1-beta-D-ribofuranosyl 5'-monophosphate
(1R,2S,3R,5R)-3-(3-aMino-5-Methyl-1,4,5,6,8-pentaazaacenaphthylen-1(5H)-yl)-5-(hydroxyMethyl)cyclopentane-1,2-diol | [Molecular Formula]
C13H17N6O7P | [MDL Number]
MFCD00866447 | [MOL File]
61966-08-3.mol | [Molecular Weight]
400.286 |
| Hazard Information | Back Directory | [Uses]
Triciribine phosphate is an Akt activation inhibitor that inhibits Akt phosphorylation by binding to the pleckstrin homology (PH) domain of the Akt and blocking its recruitment to the plasma membrane. | [Brand name]
Triciribine is INN. | [References]
[1] N BERNDT. The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane[J]. Cell Death and Differentiation, 2010, 17 11: 1795-1804. DOI: 10.1038/cdd.2010.63
[2] PLAGEMANN P G. Transport, phosphorylation, and toxicity of a tricyclic nucleoside in cultured Novikoff rat hepatoma cells and other cell lines and relase of its monophosphate by the cells.[J]. JNCI Journal of the National Cancer Institute, 1976, 57 6: 1283-1295. DOI: 10.1093/jnci/57.6.1283
[3] B C BEHRENS. Activity of tricyclic nucleoside 5’-phosphate in model systems of human ovarian cancer.[J]. Investigational New Drugs, 1986, 4 4: 295-304. DOI: 10.1007/bf00173502
[4] ANTHONY R. PORCARI. Deoxy Sugar Analogues of Triciribine: Correlation of Antiviral and Antiproliferative Activity with Intracellular Phosphorylation[J]. Journal of Medicinal Chemistry, 2000, 43 12: 2438-2448. DOI: 10.1021/jm990205m |
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