| Identification | More | [Name]
4-Amino-7H-pyrrolo[2,3-d]pyrimidine | [CAS]
1500-85-2 | [Synonyms]
4-AMINOPYRROLO[2,3-D]PYRIMIDINE
7-DEAZAADENINE
7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE
3-d)pyrimidine,4-amino-7h-pyrrolo(
4-Amino-7H-pyrrolo[2,3-d]pyrimidine
1H-Pyrrolo[2,3-d]pyrimidin-4-amine (9CI)
4-Aminopyrrolo[2,3-d]Pyrimidin
4-AMINO-7H-PYRROLO[2,3-D]PYRIMIDINE SULFATE 98% | [Molecular Formula]
C6H6N4 | [MDL Number]
MFCD01686848 | [Molecular Weight]
134.14 | [MOL File]
1500-85-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
257-262℃ | [Boiling point ]
318.3±45.0 °C(Predicted) | [density ]
1.61±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [form ]
Solid | [pka]
13.38±0.20(Predicted) | [color ]
White to pale brown | [Sensitive ]
Moisture & Light Sensitive | [InChI]
InChI=1S/C6H6N4/c7-5-4-1-2-8-6(4)10-3-9-5/h1-3H,(H3,7,8,9,10) | [InChIKey]
PEHVGBZKEYRQSX-UHFFFAOYSA-N | [SMILES]
C1=NC(N)=C2C=CNC2=N1 | [CAS DataBase Reference]
1500-85-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
25 | [Safety Statements ]
45 | [RIDADR ]
UN 2811 6.1/PG 1 | [WGK Germany ]
2 | [RTECS ]
UY8850000 | [HazardClass ]
IRRITANT | [PackingGroup ]
Ⅲ | [HS Code ]
2933599590 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral | [Toxicity]
mouse,LD50,intraperitoneal,300mg/kg (300mg/kg),Gann. Japanese Journal of Cancer Research. Vol. 56, Pg. 219, 1965. |
| Questions And Answer | Back Directory | [Application]
6-Amino-7-azapurine is a purine biological intermediate that can be used as a chemical raw material and pharmaceutical intermediate. |
| Hazard Information | Back Directory | [Synthesis]
A mixture of 5-ethynylpyrimidine-4,6-diamine (300?mg, 2.24?mmol), Cs2CO3 (1.46?g, 4.47?mmol) and DMSO (4.00?ml) in a 10.00?ml microwave tube was irradiated at 100?W and 180?°C for 15?minutes. After this time, the reaction mixture was cooled to room temperature and poured into a separating funnel containing 100?ml water and 100?ml ethyl acetate. The aqueous layer was extracted with EtOAc (2×100?ml). The combined organic extracts were dried with MgSO4 and filtered through celite, and excess solvent was removed in vacuo. Purification by column chromatography (80?% EtOAc/hexane – 10?% MeOH/CH2Cl2) gave 7H-pyrrolo[2,3-d]pyrimidin-4-amine (4-Amino-7H-pyrrolo[2,3-d]pyrimidine) (0.15?g, 50?%) as an off-white solid[1].
| [References]
[1] Dr. Tswene D. Seanego. “7H-Pyrrolo[2,3-d]pyrimidine-4-amines as Potential Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinases.” ChemMedChem 17 22 (2022). |
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