| Chemical Properties | Back Directory | [Boiling point ]
655.1±65.0 °C(Predicted) | [density ]
1.26±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
13.19±0.58(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PIP-199 is a selective inhibitor of RMI (RecQ-mediated genome instability protein) core complex/MM2 interaction, with an IC50 of 36 μM. PIP-199 can be used for the research of sensitizing resistant tumors to DNA crosslinking chemotherapeutics[1]. | [Biological Activity]
PIP-199 is a selective inhibitor of the RecQ-mediated RMI core complex/MM2 interaction of genomically unstable proteins with IC50 of 36 μM. PIP-199 can be used to sensitize resistant tumors to DNA cross-linking chemotherapeutics. | [in vitro]
MM2 is the binding site of RMI complex on Fanconi anemia complementation group M protein (FANCM).
Induction of the Fanconi anemia (FA) DNA repair pathway is a common mechanism by which tumors evolve resistance to DNA crosslinking chemotherapies.
Proper execution of the FA pathway requires interaction between the FANCM and the RMI complex, and mutations that disrupt FANCM/RMI interactions sensitize cells to DNA crosslinking agents.
| [target]
IC50: 36 μM (RMI core complex/MM2 interaction) | [storage]
Store at -20°C | [References]
[1] Andrew F. Voter, et al. A high throughput screening strategy to identify protein-protein interaction inhibitors that block the Fanconi anemia DNA repair pathway. J Biomol Screen. 2016 Jul; 21(6): 626–633. DOI:10.1177/1087057116635503 |
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| Company Name: |
cjbscvictory
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| Tel: |
13348960310 13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
| Company Name: |
MedChemExpress
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| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
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