ChemicalBook--->CAS DataBase List--->62813-01-8

62813-01-8

62813-01-8 Structure

62813-01-8 Structure
IdentificationMore
[Name]

1-Cyclopropylpiperidin-4-one
[CAS]

62813-01-8
[Synonyms]

1-CYCLOPROPYL-4-PIPERIDONE
1-CYCLOPROPYL-PIPERIDIN-4-ONE
1-CYCLOPROPYLTETRAHYDRO-4(1H)-PYRIDINONE
[EINECS(EC#)]

1533716-785-6
[Molecular Formula]

C8H13NO
[MDL Number]

MFCD07374375
[Molecular Weight]

139.19
[MOL File]

62813-01-8.mol
Chemical PropertiesBack Directory
[Boiling point ]

55°/2mm
[density ]

1.151±0.06 g/cm3(Predicted)
[storage temp. ]

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
[form ]

low melting crystals
[pka]

8.18±0.20(Predicted)
[color ]

Colourless to light yellow
[InChI]

InChI=1S/C8H13NO/c10-8-3-5-9(6-4-8)7-1-2-7/h7H,1-6H2
[InChIKey]

DTUJRJIWGWTNFQ-UHFFFAOYSA-N
[SMILES]

N1(C2CC2)CCC(=O)CC1
[CAS DataBase Reference]

62813-01-8(CAS DataBase Reference)
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302+H312+H332-H315-H319-H335
[Precautionary statements ]

P280
[RIDADR ]

1993
[HazardClass ]

IRRITANT
[PackingGroup ]

[HS Code ]

2914390090
Hazard InformationBack Directory
[Uses]

1-Cyclopropylpiperidin-4-one
[Synthesis]

3-[cyclopropyl-(2-ethoxycarbonyl-ethyl)-amino]-propionic acid ethyl ester

49683-17-2

1-Cyclopropylpiperidin-4-one

62813-01-8

Step 2: A solution of ethyl 3-[cyclopropyl-(2-ethoxycarbonyl-ethyl)-amino]-propionate (39 mmol) in anhydrous tetrahydrofuran (65 mL) was added slowly and dropwise to a solution of sodium hydride (60% oil dispersion, 58 mmol) in anhydrous tetrahydrofuran (65 mL). Anhydrous ethanol (39 mmol) was then added. The reaction mixture was heated under reflux conditions for 24 hours. Upon completion of the reaction, the reaction solution was neutralized with dilute acetic acid to pH 7 and subsequently partitioned between water and ethyl acetate. The aqueous layer was extracted with ethyl acetate, the organic phases were combined and dried over sodium sulfate. The solvent was removed by concentration under reduced pressure to give 10.2 g of red oily material. This crude product was mixed with 18% w/w hydrochloric acid (130 mL) and heated at reflux for 5 hours. At the end of the reaction, the pH was adjusted to about 12 with sodium hydroxide (about 31 g) and the crude mixture was extracted with ethyl acetate. The organic phases were combined and dried with sodium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by fractional distillation under reduced pressure (20 mbar) and the fractions with a boiling point of 75 °C (20 mbar) were collected to give 3.6 g (67% yield) of the target product 1-cyclopropyl-piperidin-4-one as a colorless oil. Mass spectrometry (MS) analysis showed m/e: 140.0 (MH+, 100%).

[References]

[1] Patent: US2006/160855, 2006, A1. Location in patent: Page/Page column 14
[2] Patent: WO2005/123716, 2005, A1. Location in patent: Page/Page column 101
[3] Chemical and Pharmaceutical Bulletin, 1980, vol. 28, # 9, p. 2653 - 2657
Spectrum DetailBack Directory
[Spectrum Detail]

1-Cyclopropylpiperidin-4-one(62813-01-8)1HNMR
Well-known Reagent Company Product InformationBack Directory
[Alfa Aesar]

1-Cyclopropyl-4-piperidone, 98%(62813-01-8)
62813-01-8 suppliers list
Company Name: Changzhou Ditong Chemical Co.,Ltd
Tel: +86-0519-88299272
Website: http://www.edengenechem.com
Company Name: Alchem Pharmtech,Inc.
Tel: 8485655694
Website: www.chemicalbook.com/ShowSupplierProductsList454175/0_EN.htm
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427 , +8618523575427
Website: http://www.conier.com/
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695 , +8613203830695
Website: www.coreychem.com
Company Name: Guangzhou Yuheng Pharmaceutical Technology Co., Ltd
Tel: +8613580539051 , +8613580539051
Website: www.yuhengpharm.com
Company Name: Blocksynth Pharmaceutical Technology Co.,Ltd
Tel: 0086-19817745290; +8619817745290 , +8619817745290
Website: http://www.blocksynth.com/
Company Name: Alfa Chemistry
Tel:
Website: www.chemicalbook.com/ShowSupplierProductsList1423038/0.htm
Company Name: Aston Chemical
Tel: 13000000000
Website: www.chemicalbook.com/ShowSupplierProductsList936904/0.htm
Company Name: Hefei Hirisun Pharmatech Co., Ltd
Tel: +8615056975894 , +8615056975894
Website: www.hirisunpharm.com
Company Name: CD Chemical Group Limited
Tel: +8615986615575 , +8615986615575
Website: http://www.codchem.com/
Company Name: Henan Alfa Chemical Co., Ltd
Tel: +8615838112936 , +8615838112936
Website: www.chemicalbook.com/manufacturer/henan-alfa-chemical-570/
Company Name: Nextpeptide Inc
Tel: +86-0571-81612335 +8613336028439 , +8613336028439
Website: http://www.nextpeptide.com/
Company Name: Labnetwork lnc.
Tel: +86-27-50766799 +8618062016861 , +8618062016861
Website: www.labnetwork.com
Company Name: GIHI CHEMICALS CO.,LIMITED
Tel: +8618058761490 , +8618058761490
Website: www.gihichem.com/
Company Name: Aladdin Scientific
Tel:
Website: www.aladdinsci.com/
Company Name: XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.
Tel: +8618950047208 , +8618950047208
Website: www.amitychem.com
Company Name: Amadis Chemical Company Limited
Tel: 571-89925085
Website: http://www.amadischem.com
Company Name: Parmax Pharma Limited  
Tel: +91-9924544911 +91-9428003765
Website: www.parmaxpharma.com
Tags:62813-01-8 Related Product Information
41661-47-6 62813-01-8

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.