| Identification | More | [Name]
2-Chloro-5-nitro-benzamine | [CAS]
6283-25-6 | [Synonyms]
1-AMINO-2-CHLORO-5-NITROBENZENE
2-AMINO-1-CHLORO-4-NITROBENZENE
2-CHLORO-5-NITROANILINE
2-chloro-5-nitro-benzamine
5-NITRO-2-CHLOROANILINE
TIMTEC-BB SBB003829
2-chloro-5-nitro-anilin
2-chloro-5-nitro-benzenamin
2-chloro-5-nitrobenzenamine
3-Nitro-6-chloroaniline
6-chloro-3-nitro-anilin
6-Chloro-3-nitroaniline
Aniline, 2-chloro-5-nitro-
anilineandchloro,bromo-,andnitro-anilines
3-AMINO-4-CHLORONITROBENZENE
Benzenamine, 2-chloro-5-nitro-
2-Chlor-5-nitroanilin | [EINECS(EC#)]
228-498-7 | [Molecular Formula]
C6H5ClN2O2 | [MDL Number]
MFCD00007668 | [Molecular Weight]
172.57 | [MOL File]
6283-25-6.mol |
| Chemical Properties | Back Directory | [Appearance]
yellow powder | [Melting point ]
118-120 °C(lit.)
| [Boiling point ]
200°C (rough estimate) | [density ]
1.5610 (rough estimate) | [refractive index ]
1.5870 (estimate) | [Fp ]
191°C | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
powder to crystal | [pka]
0.60±0.10(Predicted) | [color ]
Light yellow to Amber to Dark green | [Detection Methods]
HPLC | [BRN ]
2208878 | [InChI]
InChI=1S/C6H5ClN2O2/c7-5-2-1-4(9(10)11)3-6(5)8/h1-3H,8H2 | [InChIKey]
KWIXNFOTNVKIGM-UHFFFAOYSA-N | [SMILES]
C1(N)=CC([N+]([O-])=O)=CC=C1Cl | [CAS DataBase Reference]
6283-25-6(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzenamine, 2-chloro-5-nitro-(6283-25-6) | [EPA Substance Registry System]
6283-25-6(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
T+,N | [Risk Statements ]
R26/27/28:Very Toxic by inhalation, in contact with skin and if swallowed .
R33:Danger of cumulative effects.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S60:This material and/or its container must be disposed of as hazardous waste .
S13:Keep away from food, drink and animal feeding stuffs . | [RIDADR ]
UN 2237 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
BX1500000
| [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29215900 | [Hazardous Substances Data]
6283-25-6(Hazardous Substances Data) |
| Hazard Information | Back Directory | [Chemical Properties]
yellow powder | [Uses]
2-Chloro-5-nitroaniline is a chemical reagent used in the synthesis anti-inflammatory 1,1-dioxido propenone derivatives. | [Synthesis]
General procedure: Catalyst 1 (10 mol%), 2-bromo-5-nitroaniline (1.0 mmol), tetramethylammonium chloride (Me4NCl, 2.0 mmol) and ethanol (EtOH, 2.0 mL) were sequentially added to the Schlenk tube under nitrogen protection. The Schlenk tube was sealed using a polytetrafluoroethylene (Teflon) valve and the reaction mixture was stirred at 100 °C for the reaction time referred to in Table 2 (the reaction process was monitored by gas chromatography (GC)). Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate = 10/1) to give 2-chloro-5-nitroaniline. The product yield was determined by high-resolution gas chromatography-mass spectrometry (GC-MS) analysis, and the structure was confirmed by comparing its physical properties and spectral data with known compounds. | [References]
[1] Applied Catalysis A: General, 2014, vol. 472, p. 178 - 183 |
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