| Identification | Back Directory | [Name]
2-[2-(2-AMINOETHOXY)ETHOXY]ETHANOL | [CAS]
6338-55-2 | [Synonyms]
MA 10
T3EGMA
NSC40760
Amino-PEG3
HO-PEG3-NH2
H2N-PEG3-OH
NH2-PEG3-OH
Triglycolamine
PROTAC Linker 35
(PEO)3-mono-amine
Amino-PEG3-alcohol
3,6,9-Trioxadecylamine
Triethylene Glycolamine
8-Amino-3,6-dioxaoctanol
AMINOETHOXY ETHOXY ETHANOL
8-Amino-3,6-dioxa-1-octanol
Triethylene glycol monoamine
H2N-PEG3-OH
2-[2-(2-AMINOETHOXY)ETHOXY]ETHANOL
Ethanol, 2-(2-(2-aminoethoxy)ethoxy)-
2-[2-(2-Hydroxyethoxy)ethoxy]ethylamine
2-[2-(2-Aminoethoxy)ethoxy]ethanol >=96.0% (GC) | [EINECS(EC#)]
804-174-6 | [Molecular Formula]
C6H15NO3 | [MDL Number]
MFCD07367495 | [MOL File]
6338-55-2.mol | [Molecular Weight]
149.19 |
| Chemical Properties | Back Directory | [Boiling point ]
120-130℃ (4 Torr) | [density ]
1.0773 g/cm3at 20℃(lit.) | [refractive index ]
1.4645 (589.3 nm 20℃) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
DMF: 30 mg/ml; DMSO: 10 mg/ml; Ethanol: 15 mg/ml; PBS (pH 7.2): 10 mg/ml | [form ]
clear liquid | [pka]
14.36±0.10(Predicted) | [color ]
Colorless to Light yellow to Light orange | [Appearance]
colorless liquid | [BRN ]
1739188 | [InChI]
InChI=1S/C6H15NO3/c7-1-3-9-5-6-10-4-2-8/h8H,1-7H2 | [InChIKey]
ASDQMECUMYIVBG-UHFFFAOYSA-N | [SMILES]
C(O)COCCOCCN | [CAS DataBase Reference]
6338-55-2 | [EPA Substance Registry System]
Ethanol, 2-[2-(2-aminoethoxy)ethoxy]- (6338-55-2) |
| Hazard Information | Back Directory | [Description]
(PEO)3-monoamine is a poly(ethylene oxide) (PEO) blocking reagent that prevents nonspecific adsorption of analytes in applications using covalent protein coupling such as ELISA.1 It reduces the adsorption of IgG when coated on carboxylic-terminated surfaces. | [Uses]
(PEO)3-Mono-amine can be used as a novel improved cutting fluid. | [General Description]
NH₂-PEG₃-OH (CAS 6338-55-2) is a high-purity, discrete, hetero-bifunctional PEG linker. Its synonyms include Amino-PEG3, Amine-PEG3-OH, (PEO)3-MONO-AMINE, Amino-PEG3-alcohol and 2-[2-(2-aminoethoxy)ethoxy]ethanol, amongst others. The NH₂-PEG₃-OH molecule consists of three parts: an amino group, a short chain comprising three PEG units, and a hydroxyl group. It can be used for peptide modification, the synthesis of small-molecule targeted drugs, ADCs and PROTACs. The amino group can react with carboxylic acids, activated NHS esters, and carbonyl groups (ketones, aldehydes); the hydroxyl group can be further converted into other functional groups. The PEG chains help to improve the solubility and stability of the drug. | [Synthesis]
The general procedure for the synthesis of 2-[2-(2-aminoethoxy)ethoxy]ethanol from 2-(2-(2-azidoethoxy)ethoxy)ethanol was as follows: 2-(2-(2-azidoethoxy)ethoxy)ethanol (0.7 g, 3.99 mmol) was dissolved in methanol (9 mL), followed by addition of a palladium/activated carbon catalyst (0.196 g) under stirring conditions . The reaction flask was subjected to three evacuation/hydrogen flush cycles to establish a hydrogen atmosphere. The progress of the reaction was monitored by thin layer chromatography (TLC), which showed the completion of the reaction after 8 hours. The reaction mixture was filtered through diatomaceous earth to remove the palladium/activated carbon catalyst. The filtrate was concentrated under reduced pressure to afford 2-[2-(2-aminoethoxy)ethoxy]ethanol as a colorless oil (0.6 g, quantitative yield). | [IC 50]
PEGs | [References]
[1] Helvetica Chimica Acta, 1991, vol. 74, # 8, p. 1697 - 1706
[2] Patent: US5144043, 1992, A
[3] Organic Letters, 2009, vol. 11, # 1, p. 193 - 196
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 2, p. 1151 - 1155
[5] Angewandte Chemie - International Edition, 2015, vol. 54, # 35, p. 10327 - 10330 |
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Energy Chemical
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