| Identification | Back Directory | [Name]
Merck SIP Agonist | [CAS]
635701-59-6 | [Synonyms]
CS-126
CAY10734
Merck SIP Agonist
SHQNRSGKLNMHOS-UHFFFAOYSA-N
butylphenyl)-1,2,4-oxadiaz1-(4-(5-(4-isool-3-yl)benzyl)azetidine-3-carboxylic acid
1-(4-(5-(4-Isobutylphenyl)-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylic acid
1-[4-[5-[4-(2-Methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]benzyl]azetidine-3-carboxylic acid
1-[[4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-ly]phenyl]methyl]-3-Azetidinecarboxylic acid
3-Azetidinecarboxylic acid, 1-[[4-[5-[4-(2-methylpropyl)phenyl]-1,2,4-oxadiazol-3-yl]phenyl]methyl]- | [Molecular Formula]
C23H25N3O3 | [MDL Number]
MFCD11977297 | [MOL File]
635701-59-6.mol | [Molecular Weight]
391.469 |
| Chemical Properties | Back Directory | [Boiling point ]
565.9±60.0 °C(Predicted) | [density ]
1.228±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 5 mg/ml; DMF:PBS (pH 7.2) (1:10): 0.1 mg/ml; Ethanol: Partially soluble | [form ]
A crystalline solid | [pka]
2.66±0.20(Predicted) |
| Hazard Information | Back Directory | [Description]
CAY10734 is an agonist of sphingosine-1-phosphate receptor 1 (S1P1; IC50 = 0.6 nM). It selectively binds S1P1 over S1P2, S1P3, and S1P4 receptors (IC50s = >10,000, 12,000, and 70 nM, respectively) but does also bind S1P5 receptors (IC50 = 1 nM) in radioligand binding assays. CAY10734 reduces the number of peripheral blood lymphocytes in mice, rats, and dogs, with the maximal response achieved when administered at doses of 10, 0.5, and 0.5 mg/kg, respectively. It increases graft survival in a rat skin allograft model when administered at a dose of 5 mg/kg per day in combination with cyclosporin A (CsA; ). | [References]
[1] ZHEN LI. Discovery of Potent 3,5-Diphenyl-1,2,4-oxadiazole Sphingosine-1-phosphate-1 (S1P1) Receptor Agonists with Exceptional Selectivity against S1P2 and S1P3[J]. Journal of Medicinal Chemistry, 2005, 48 20: 6169-6173. DOI: 10.1021/jm0503244 |
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BOC Sciences
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1-631-485-4226; 16314854226 |
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https://www.bocsci.com |
| Company Name: |
BOC Sciences
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16314854226 |
| Website: |
www.bocsci.com |
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Cckinase, Inc.
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+1 (732)236-3202 |
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www.cckinase.com |
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