| Identification | Back Directory | [Name]
Paroxetine maleate | [CAS]
64006-44-6 | [Synonyms]
gf74
FG-7051
BRL-29060
fg7051maleate
PAROXETINE MALEATE
,(z)-2-butenedioate
Paroxetine maleate salt
Paroxetine maleate solution
3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-3-((trans-(-)-piperidin
(-)-alpha-4-(4-fluorophenyl)-3-(1,3-benzdioxolyl-(3))-oxymethylpiperidinema
trans-(-)-3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidinem
(3S,4R)-3-[(1,3-BENZODIOXOL-5-YLOXY)METHYL]-4-(4-FLUOROPHENYL)-PIPERIDINE MALEATE
(3S-TRANS)-3-[(1,3-BENZODIOXOL-5-YLOXY)METHYL]-4-(4-FLUOROPHENYL)PIPERIDINE MALEATE
(3S-trans)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine maleate salt
BRL-29060, FG-7051, (3S-trans)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine maleate
Paroxetine maleate salt,(3S-trans)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine maleate salt, BRL-29060, FG-7051 | [EINECS(EC#)]
636-343-3 | [Molecular Formula]
C23H24FNO7 | [MDL Number]
MFCD01742665 | [MOL File]
64006-44-6.mol | [Molecular Weight]
445.44 |
| Chemical Properties | Back Directory | [Melting point ]
136-138°C | [alpha ]
D -87° (c = 5 in ethanol) | [Fp ]
9℃ | [storage temp. ]
2-8°C | [solubility ]
DMSO: ~12 mg/mL | [form ]
solid | [color ]
white |
| Hazard Information | Back Directory | [Uses]
Paroxetine maleate is a selective serotonin uptake inhibitor. | [Definition]
ChEBI: A maleate salt obtained by reaction of paroxetine with one equivalent of maleic acid. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibi
ion of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2 | [General Description]
Paroxetine, marketed under trade names such as Paxil? or Aropax, is an SSRI antidepressant used to treat many conditions in adults from major depression and obsessive-compulsive disorder to several anxiety disorders. Suitable uses for this certified solution standard include as a starting material for calibrators and controls in LC/MS or GC/MS paroxetine testing applications such as urine drug testing, prescription monitoring, clinical toxicology, or forensic analysis. | [Biological Activity]
Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (K i = 0.05 nM). K i values are 1.1, 350 and 1100 nM for inhibition of [ 3 H]-5-HT, [ 3 H]-l-NA and [ 3 H]-DA uptake respectively. Displays minimal affinity for a 1 -, a 2 - or b-adrenoceptors, 5-HT 2A , 5-HT 1A , D 2 or H 1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (K i = 42 nM). Antidepressant and anxiolytic in vivo . | [Biochem/physiol Actions]
Paroxetine is a strong cytochrome P450 2D6 isotype (CYP2D6) inhibitor, which reduces the effectiveness of tamoxifen. This phenylpiperidine derivative inhibits clozapine metabolism. Paroxetine is used to treat social phobia, obsessive-compulsive disorder and panic disorder. It is also used to treat the premenstrual dysphoric disorder, post-traumatic stress disorder and chronic headache. | [storage]
Store at RT |
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Sigma-Aldrich
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https://www.sigmaaldrich.cn |
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BOC Sciences
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https://www.bocsci.com |
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