| Identification | Back Directory | [Name]
Nimorazole | [CAS]
6506-37-2 | [Synonyms]
K-1900
Naxogin
Acterol
Esclama
Nulogyl
Nimorazol
NIMORAZOLE
Nitrimidazine
Acterol forte
Nimorazole, >=98%
Nimorazole USP/EP/BP
Nimorazole, 6506-37-2
NITRIMIDAZINE; NAXOGIN
1-( -Morpholinoethyl)-5-nitroimidazole
4-(2-NITROIMIDAZOL-1-YL)ETHYL)MORPHOLINE
1-(2-N-Morpholinylethyl)-5-nitroimidazole
4-[2-(5-Nitroimidazol-1-yl)ethyl]morpholine
1-(.beta.-Morpholinoethyl)-5-nitroimidazole
Morpholine, 4-[2-(5-nitroimidazol-1-yl)ethyl]-
4-[2-(5-Nitro-1H-imidazol-1-yl)ethyl]morpholine
Morpholine, 4-[2-(5-nitro-1H-imidazol-1-yl)ethyl]-
Nimorazole 4-[2-(5-Nitroimidazol-1-yl)ethyl]morpholine | [EINECS(EC#)]
229-394-4 | [Molecular Formula]
C9H14N4O3 | [MDL Number]
MFCD00866796 | [MOL File]
6506-37-2.mol | [Molecular Weight]
226.23 |
| Chemical Properties | Back Directory | [Melting point ]
110-111° | [Boiling point ]
367.84°C (rough estimate) | [density ]
1.2673 (rough estimate) | [refractive index ]
1.6300 (estimate) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
6.65±0.10(Predicted) | [color ]
Off-White to Yellow | [InChI]
InChI=1S/C9H14N4O3/c14-13(15)9-7-10-8-12(9)2-1-11-3-5-16-6-4-11/h7-8H,1-6H2 | [InChIKey]
MDJFHRLTPRPZLY-UHFFFAOYSA-N | [SMILES]
N1(CCN2C=NC=C2[N+]([O-])=O)CCOCC1 | [CAS DataBase Reference]
6506-37-2 | [NIST Chemistry Reference]
Nimorazole(6506-37-2) |
| Hazard Information | Back Directory | [Description]
Nimorazole is 5-nitroimidazole with antimicrobial and radiosensitizing activities.1,2,3 It is active against T. vaginalis in a Coulter counter antimicrobial assay (EC50 = 2.55 fmol/cell) and G. intestinalis (IC50 = 0.393 μM).1,2 Nimorazole reduces the number of vaginal trichomonads in a mouse model of T. vaginalis intravaginal infection (ED50 = 5.62 mg/kg).4 Under hypoxic conditions, nimorazole enhances radiation-induced SCC-7 tumor cell death in vitro and in vivo.3 | [Originator]
Naxogin,Carlo Erba,UK,1970 | [Uses]
Nimorazole is an antimicrobial with activity against anaerobic bacteria and protozoa. | [Definition]
ChEBI: Nimorazole is a member of imidazoles and a C-nitro compound. | [Manufacturing Process]
6 g 4(5)-nitroimidazole sodium salt and 9 g β-chloroethylmorpholine are
allowed to react in 200 ml dry toluene. The mixture is refluxed for 50 hours,
then cooled and filtered from the solid residue. The solvent is evaporated
under reduced pressure. The half-solid product thus obtained solidifies by
addition of petroleum ether and ethyl ether.
Crystallization from water results in N-β-ethylmorpholino-(5)-nitroimidazole
(melting point 110°C to 111°C); from mother liquors N-β-ethylmorpholino-
(4)-nitroimidazole (melting point 104°C to 106°C) is obtained.
The following procedure is given in US Patent 3,458,528: 78 grams (0.675
mol) of 5-nitroimidazole is dissolved in 1,500 ml of acetic acid upon the
addition of 72 ml (0.57 mol) of boron trifluoride etherate. 175 ml (3.5 mols)
of ethylene oxide in 175 ml of hexane, in a dropping funnel topped with a cold finger, is added slowly over 1 hour to the above solution maintained at 32° to
35°C with a water cooling bath. The mixture is concentrated under high
vacuum to 100 to 150 ml volume. The residue is diluted with 500 ml of water,
neutralized to pH 7 with aqueous sodium hydroxide, and extracted with 1.5
liters of ethyl acetate. The extract is dried and evaporated to yield 1-(2'-
hydroxyethyl)-5-nitroimidazole.
20 grams (0.127 mols) of 1-(2'-hydroxyethyl)-5-nitroimidazole in 50 ml of dry
pyridine is reacted with 75 grams of p-toluenesulfonyl chloride at 15°C for 4
hours. The reaction mixture is poured into ice and water and the crystalline
precipitate is separated by filtration, washed with water and air dried to yield
1-(2'-p-toluenesulfonyloxyethyl)-5-nitroimidazole; MP 126° to 127°C.
16 grams, (0.057 mol) of 1-(2'-p-toluenesulfonyloxyethyl)-5-nitroimidazole
and 9.3 ml of morpholine are heated at 95°C for 4 hours. The reaction
mixture is taken up in water and extracted with ether. Evaporation of the
ether yields 1-(2'-N-morpholinylethyl)-5-nitroimidazole; MP 109° to 110°C. | [Therapeutic Function]
Trichomonacidal | [Pharmaceutical Applications]
An orally administered 5-nitroimidazole. It is slightly soluble in water at room temperature, soluble in alcohols, acetone and chloroform. The spectrum includes T. vaginalis, G. lamblia, E. histolytica, anaerobic bacteria and G. vaginalis. Activity against B. fragilis and Fusobacterium spp. is similar to or slightly less than that of metronidazole (mean MIC 0.25–1 mg/L).
A peak blood concentration of about 32 mg/L occurs within 2 h of a 500 mg oral dose. High concentrations are achieved in saliva and vaginal secretions. Excretion is principally via the urine where the drug appears as metabolites which display antimicrobial and antiprotozoal activity less than that of the parent drug.
It is generally well tolerated even at the high doses required in conjunction with radiotherapy for the treatment of head and neck tumors. Adverse effects are the same as those of metronidazole. Disulfiram-like reactions appear to be rare.
Clinical uses are similar to those of metronidazole. It is also used as a hypoxic radiosensitizer in the radiotherapy of head and neck tumors. | [storage]
Store at -20°C | [References]
[1] BROTHERTON J. Biological assay of potential trichomonacides in vitro using a counter apparatus.[J]. Arzneimittel-Forschung-Drug Research, 1978, 28 10: 1665-1672.
[2] P F BOREHAM R W S R E Phillips. A comparison of the in-vitro activity of some 5-nitroimidazoles and other compounds against Giardia intestinalis.[J]. Journal of Antimicrobial Chemotherapy, 1985, 16 5: 589-595. DOI: 10.1093/jac/16.5.589
[3] HORI C S S I O S U N. Reevaluation of the Radiosensitizing Effects of Sanazole and Nimorazole In Vitro and In Vivo[J]. Journal of Radiation Research, 2005, 46 4: 453-459. DOI: 10.1269/jrr.46.453
[4] MEINGASSNER J G. Comparative studies on the trichomonacidal activity of 5-nitroimidazole-derivatives in mice infected s.c. or intravaginally with T. vaginalis.[J]. Experientia, 1977, 33 9: 1160-1161. DOI: 10.1007/bf01922302 |
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D&C Chemicals
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