| Identification | Back Directory | [Name]
2,3,6-TRICHLOROPYRIDINE | [CAS]
6515-09-9 | [Synonyms]
2,3,6-TrichL
2,5,6-Trichloropyridine
Pyridine,2,3,6-trichloro
2,6-Dichloro-3-chloropyridine
2,3,6-TRICHLOROPYRIDINE ISO 9001：2015 REACH | [EINECS(EC#)]
1592732-453-0 | [Molecular Formula]
C5H2Cl3N | [MDL Number]
MFCD00463516 | [MOL File]
6515-09-9.mol | [Molecular Weight]
182.44 |
| Chemical Properties | Back Directory | [Melting point ]
66-67 °C | [Boiling point ]
300.44°C (rough estimate) | [density ]
1.8041 (rough estimate) | [refractive index ]
1.6300 (estimate) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
soluble in Methanol | [form ]
powder to crystal | [pka]
-3.79±0.10(Predicted) | [color ]
Light yellow to Brown | [InChI]
InChI=1S/C5H2Cl3N/c6-3-1-2-4(7)9-5(3)8/h1-2H | [InChIKey]
GPAKJVMKNDXBHH-UHFFFAOYSA-N | [SMILES]
C1(Cl)=NC(Cl)=CC=C1Cl | [EPA Substance Registry System]
2,3,6-Trichloropyridine (6515-09-9) |
| Hazard Information | Back Directory | [Uses]
2,3,6-Trichloropyridine can be used as a catalyst for various compounds, such as, 2,3-dichloropyridine. This compound can also be used as an intermediate in chemosynthesis. | [Safety Profile]
A poison by intraperitoneal route.When heated to decomposition it emits toxic vapors ofNOx and Clí. | [Synthesis]
The general procedure for the synthesis of 2,3,6-trichloropyridine from 2,6-dichloropyridine was as follows: 2,6-dichloropyridine 1480.0 g and anhydrous FeCl3 89.2 g were accurately weighed, mixed thoroughly and transferred to a 2000 mL four-neck flask. The reaction mixture was heated to 100-120 °C and then chlorine gas was slowly introduced until the reaction was complete. Upon completion of the reaction, the system was cooled to 100 °C and subsequently subjected to decompression distillation. Fractions with boiling points of 118-124°C were collected as products at a pressure of -12.8 MPa. The low concentration of distillate produced during the distillation process can be recycled for the next batch of reaction. Eventually, 1715.0 g of 2,3,6-trichloropyridine was obtained by recycling the distillate in 94.0% yield, and the purity of the product was in accordance with the requirements. | [References]
[1] Patent: EP2687510, 2014, A1. Location in patent: Paragraph 0011
[2] Patent: CN107759512, 2018, A. Location in patent: Paragraph 0021-0022 |
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