| Identification | More | [Name]
2,6-Dichloropyridine | [CAS]
2402-78-0 | [Synonyms]
26DCLPY
2,6-DICHLOROPYRIDINE
AKOS BBS-00004314
AURORA KA-6495
2,6-dichloro-pyridin
2,6-Dichloropyridine,97%
Pyridine, 2,6-dichloro-
2,6-Dichloropyridinr
2,6-Dichloropyridine ,98% | [EINECS(EC#)]
219-282-3 | [Molecular Formula]
C5H3Cl2N | [MDL Number]
MFCD00006244 | [Molecular Weight]
147.99 | [MOL File]
2402-78-0.mol |
| Chemical Properties | Back Directory | [Appearance]
White to light yellow solid | [Melting point ]
83-86 °C (lit.) | [Boiling point ]
211 °C | [density ]
1.5159 (rough estimate) | [refractive index ]
1.5500 (estimate) | [Fp ]
110°C | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
methanol: 50 mg/mL, clear
| [form ]
Crystalline Powder | [pka]
-3.02±0.10(Predicted) | [color ]
White to pink or grayish-white | [PH]
6-7 (H2O, 20℃)(saturated solution) | [Water Solubility ]
<1 g/L (20 ºC) | [Detection Methods]
HPLC,NMR | [BRN ]
108664 | [InChIKey]
FILKGCRCWDMBKA-UHFFFAOYSA-N | [CAS DataBase Reference]
2402-78-0(CAS DataBase Reference) | [NIST Chemistry Reference]
Pyridine, 2,6-dichloro-(2402-78-0) | [EPA Substance Registry System]
2402-78-0(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
T,Xn | [Risk Statements ]
R25:Toxic if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R22:Harmful if swallowed.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 2811 6.1/PG 2
| [WGK Germany ]
3
| [RTECS ]
US8400000
| [Hazard Note ]
Toxic | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29333999 | [Toxicity]
mouse,LD50,intraperitoneal,115mg/kg (115mg/kg),BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)LIVER: FATTY LIVER DEGERATIONBEHAVIORAL: ANTIPSYCHOTIC,Toxicology and Applied Pharmacology. Vol. 11, Pg. 361, 1967. |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Pyridine-->2-CHLORO-6-FLUOROPYRIDINE | [Preparation Products]
4-Amino-2,6-dichloropyridine-->3-Amino-6-chloropyridine-2-carboxylic acid-->2-Amino-6-methoxypyridine-->2,4,6-Trichloropyridine-->2-Amino-6-chloro-3-nitropyridine-->6-Chloropyridn-2-ol-->2,6-DIETHYNYLPYRIDINE-->2,6-Dichloro-1-fluoropyridinium triflate-->2,6-Di(1-pyrazolyl)pyridine-->4,6-Dichloropyrido[3,2-d]pyrimidine-->2,6-DICHLORO-4-METHOXY-PYRIDINE-->2,6-DICHLOROPYRIDINE-3,4-DIAMINE-->2,6-Dichloroisonicotinonitrile-->2-Amino-6-methoxy-3-nitropyridine-->2-CHLORO-9H-PYRIDO[2,3-B]INDOLE-->2,6-DICHLORO-3-NITRO-4-AMINOPYRIDINE-->3-Chloropyridine |
| Hazard Information | Back Directory | [Description]
2,6-Dichloropyridine is an important intermediate that is widely used in the medicine and pesticide research field. It could be used as a starting material to synthesize the pirozadil (Pirozadil) which can be used for reducing blood-fat, and antiplatelet condensation. 2,6-dichloropyridine also can be used to synthetic musk pyridine with alternative natural musk. 2,3,5, 6-TCP produced by further chlorination of 2, 6-dichloropyridine is an important raw material for chlorpyrifos, which is widely used in the world with high efficiency, broad spectrum, and low residue.
| [Synthesis]
2-chloropyridine or 2-chloropyridine hydrochloride reacting with chlorine under photoinitiation actions at 160-190 ℃ to generate the 2,6-dichloropyridine. | [Chemical Properties]
White to light yellow solid | [Uses]
2,6-Dichloropyridine is used in the preparation of triazolo and imidazo potassium channel antagonists as antiarrythmic agents. | [Purification Methods]
It crystallises from EtOH. [Beilstein 20/5 V 416.] |
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