| Identification | Back Directory | [Name]
Pyridazin-3-ylmethanol | [CAS]
37444-46-5 | [Synonyms]
RARECHEM AM LA 0035
3-PYRIDAZINEMETHANOL
3-PYRIDAZINYLMETHANOL
PYRIDAZIN-3-YLMETHANOL
3-(HYDROXYMETHYL)PYRIDAZINE
3-(Hydroxymethyl)pyridazi...
Pyridazin-3-ylmethanol ISO 9001：2015 REACH
(Pyridazin-3-yl)methanol, 3-(Hydroxymethyl)-1,2-diazine | [Molecular Formula]
C5H6N2O | [MDL Number]
MFCD04972629 | [MOL File]
37444-46-5.mol | [Molecular Weight]
110.11 |
| Chemical Properties | Back Directory | [Melting point ]
66 °C(Solv: ethyl ether (60-29-7); ligroine (8032-32-4)) | [Boiling point ]
150 °C(Press: 1 Torr) | [density ]
1.227±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [form ]
solid | [pka]
13.41±0.10(Predicted) | [color ]
Yellow | [InChI]
InChI=1S/C5H6N2O/c8-4-5-2-1-3-6-7-5/h1-3,8H,4H2 | [InChIKey]
STIKETVNLGXQCS-UHFFFAOYSA-N | [SMILES]
C1(CO)=NN=CC=C1 |
| Questions And Answer | Back Directory | [Uses]
Pyridazine compounds have wide applications in medicine and pesticides due to their unique physiological activities. Pyridazine-3-ylmethanol is a common pyridazine compound, widely used as a pharmaceutical and chemical intermediate. |
| Hazard Information | Back Directory | [Synthesis]
To a solution of ethyl pyridazine-3-carboxylate (0.641 g, 4.21 mmol) in THF (20 mL) at 0 °C has added a solution of lithium aluminium hydride in tetrahydrofuran (1.0 M, 4.21 mL, 4.21 mmol) dropwise. The resulting suspension was stirred for 30 min. Solid Na2S04 *10 H20 was added, and the mixture was diluted with EtOAc and stirred for lh. The mixture was filtered through a pad of celite, and the residual solid was washed with EtOAc several times. The filtrate was concentrated under reduced pressure. The crude product was purified by silica gel chromatography to afford the product Pyridazin-3-ylmethanol as a brown solid (120 mg 26 percent).
| [References]
[1] Patent: WO2018/89786, 2018, A1. Location in patent: Paragraph 00398 |
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J & K SCIENTIFIC LTD.
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Tetranov Biopharm
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ZEROSCHEM.CO.,LTD.
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