| Identification | Back Directory | [Name]
Apramycin sulfate | [CAS]
65710-07-8 | [Synonyms]
Ai3-29795
NEBRAMYCIN II
ApraMycin sulf
Nebramycin 11
Unii-8uyl6naz3q
Einecs 265-890-7
Apramycin sulfate
AMPRAMYCINSULFATE
APRAMYCIN SULPHATE
Apramycin sulfater
NEBRAMYCIN II SULFATE
NEBRAMYCIN 11 SULPHATE
APRAMYCIN SULFATE SALT
AMpraMycin sulfate API
Apramycin·sulfuric acid
Apramycin, sulfate (2:5)
Apramycin sulfate salt, >500U/mg
Apramycin sulfate solution,1000ppm
Apramycin sulfate salt,Nebramycin II
Apramycin sulfate Solution Solution, 100ppm
Apramycin sulfate solution in Methanol, 100μg/mL
5-AMINO-2-[[9-AMINO-8-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXOXY)-5-HYDROXY-4-METHYLAMINO-2,7-DIOXABICYCLO[4.4.0]DEC-3-YL]OXY]-6-(HYDROXYMETHYL)OXANE-3,4-DIOL
O-4-AMino-4-deoxy-α-D-glucopyranosyl-(18)-O-(8R)-2-aMino-2,3,7-trideoxy-7-(MethylaMino)-D-glycero-α-D-allo-octodialdo-1,5:8,4-dipyranosyl-(14)-2-deoxy-D-streptaMineSulfate
4-O-[(8R)-8-O-(4-Amino-4-deoxy-α-D-glucopyranosyl)-2-amino-7-methylamino-2,3,7-trideoxy-α-D-glycero-D-allo-octodialdo-1,5:8,4-dipyranosyl]-2-deoxy-D-streptamine/sulfuric acid,(1:x)
D-Streptamine, O-4-amino-4-deoxy-α-D-glucopyranosyl-(1→8)-O-(8R)-2-amino-2,3,7-trideoxy-7-(methylamino)-D-glycero-α-D-allo-octodialdo-1,5:8,4-dipyranosyl-(1→4)-2-deoxy-, sulfate (1:)
D-Streptamine, o-4-amino-4-deoxy-alpha-D-glucopyranosyl-(1-8)-o-(8R)-2-amino-2,3,7-trideoxy-7-(methylamino)-D-glycero-alpha-D-allo-octadialdo-1,5:8,4-dipyranosyl-(1-4)-2-deoxy-, sulfate (salt)
D-Streptamine, O-4-amino-4-deoxy-.alpha.-D-glucopyranosyl-(1?8)-O-(8R)-2-amino-2,3,7-trideoxy-7-(methylamino)-D-glycero-.alpha.-D-allo-octodialdo-1,5:8,4-dipyranosyl-(1?4)-2-deoxy-, sulfate (salt)
4-O-((8R)-2-Amino-8-O-(4-amino-4-deoxy-alpha-D-glucopyranosyl)-2,3,7-trideoxy-7-(methylamino)-D-glycero-alpha-D-allo-octodialdo-1,5:8,4-dipyranos-1-yl)-2-deoxy-D-streptamine sulfate C21H41N5O11 .XH2SO4 | [EINECS(EC#)]
265-890-7 | [Molecular Formula]
C21H43N5O15S | [MDL Number]
MFCD06200257 | [MOL File]
65710-07-8.mol | [Molecular Weight]
637.66 |
| Chemical Properties | Back Directory | [Melting point ]
>168°C (dec.) | [Boiling point ]
823℃ | [density ]
1.56 | [Fp ]
451.6°(845°F) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
H2O: soluble25mg/mL | [form ]
powder | [color ]
white to light yellow | [Water Solubility ]
Soluble in water. | [JECFA Number]
75 | [InChIKey]
WGLYHYWDYPSNPF-RQFIXDHTSA-N | [SMILES]
OS(O)(=O)=O.CN[C@H]1[C@@H](O)[C@H]2O[C@H](O[C@@H]3[C@@H](N)C[C@@H](N)[C@H](O)[C@H]3O)[C@H](N)C[C@@H]2O[C@@H]1O[C@H]4O[C@H](CO)[C@@H](N)[C@H](O)[C@H]4O |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Yellow Solid | [Uses]
antibacterial; LD50(iv) 280mg/kg(mouse) | [Uses]
Apramycin sulfate is a broad spectrum aminocyclitol antibiotic and component of the Nebramycin complex, produced by a strain of Streptomyces tenebrarius. Antibacterial.
| [Definition]
ChEBI: Apramycin sulfate is a glycoside and an amino cyclitol. | [in vivo]
Apramycin (200 mg/kg/d, s.c., 9 d) sulfate demonstrates significant in vivo efficacy in lungs of M. tuberculosis low-dose aerosol infection model IFN-γ knockout mice[2].
Apramycin (16, 32, 80 mg/kg, s.c., 24 h) sulfate dose-dependently reduces bacterial burden in the kidneys between 2-5 log10 and in blood between 2-3 log10 for neutropenic model of Staphylococcus aureus septicemia mice[2].
Apramycin (50 mg/kg/d, s.c., 21 d) sulfate induces nephrotoxicity scores comparable to those induced by Gentamicin (10 mg/kg/d)[3].
| Animal Model: | M. tuberculosis low-dose aerosol infection model of IFN-γ knockout mice [2] | | Dosage: | 200 mg/kg/d | | Administration: | Subcutaneousinjection (s.c.) for 9 d | | Result: | Showed a 2.4-log10 CFU reduction and better antituberculous activity compared to Amikacin (1.8-log10 reduction). |
| [IC 50]
Aminoglycoside |
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