| Identification | Back Directory | [Name]
Propanedioic acid,2-[(2-nitrophenyl)methylene]-, 1,3-dimethyl ester | [CAS]
65974-52-9 | [Synonyms]
NCI126224
Propanedioic acid,2-[(2-nitrophenyl)methylene]-, 1,3-dimethyl ester | [Molecular Formula]
C12H11NO6 | [MOL File]
65974-52-9.mol | [Molecular Weight]
265.219 |
| Hazard Information | Back Directory | [Uses]
NCI126224 is a TLR4 signaling inhibitor. NCI126224 suppress LPS (HY-D1056)-induced production of NF-κB, TNF-α, IL-1β, and NO in the nanomolar-low micromolar range. NCI126224 can be used for the research of inflammatory diseases[1]. | [References]
[1] Zhang S, et, al. Selection, synthesis, and anti-inflammatory evaluation of the arylidene malonate derivatives as TLR4 signaling inhibitors. Bioorg Med Chem. 2012 Oct 15;20(20):6073-9. DOI:10.1016/j.bmc.2012.08.022 |
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| Company Name: |
Biorbyt Ltd.
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| Tel: |
+44 (0)1223 859 353 |
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http://www.biorbyt.com |
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