| Identification | More | [Name]
6-HYDROXYFLAVONE | [CAS]
6665-83-4 | [Synonyms]
6-HYDROXYFLAVONE
HYDROXYFLAVONE, 6-
TIMTEC-BB SBB000766
6-hydroxy-2-phenyl-4-benzopyrone
6-Hydroxyflavone,98%
HYDROXYFLAVONE, 6-(RG)
2-Phenyl-6-hydroxy-4H-1-benzopyran-4-one
6-Hydroxy-2-phenyl-4-chromenone
6-Hydroxy-2-phenyl-4H-1-benzopyran-4-one | [EINECS(EC#)]
229-704-8 | [Molecular Formula]
C15H10O3 | [MDL Number]
MFCD00017329 | [Molecular Weight]
238.24 | [MOL File]
6665-83-4.mol |
| Chemical Properties | Back Directory | [Appearance]
light yellow crystals | [Melting point ]
234-236 °C (lit.) | [Boiling point ]
320.83°C (rough estimate) | [density ]
1.2653 (rough estimate) | [refractive index ]
1.5740 (estimate) | [form ]
powder to crystal | [pka]
8.98±0.40(Predicted) | [color ]
Light yellow to Yellow to Green | [BRN ]
15827 | [InChI]
1S/C15H10O3/c16-11-6-7-14-12(8-11)13(17)9-15(18-14)10-4-2-1-3-5-10/h1-9,16H | [InChIKey]
GPZYYYGYCRFPBU-UHFFFAOYSA-N | [SMILES]
Oc1ccc2OC(=CC(=O)c2c1)c3ccccc3 | [LogP]
4.445 (est) | [CAS DataBase Reference]
6665-83-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HS Code ]
2932.99.7000 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
light yellow crystals | [Uses]
anxiolytic | [Definition]
ChEBI: 6-Hydroxyflavone is a hydroxyflavonoid. | [Synthesis Reference(s)]
Tetrahedron Letters, 27, p. 2751, 1986 DOI: 10.1016/S0040-4039(00)84634-1 | [in vivo]
6-Hydroxyflavone (6-100 mg/kg; Oral administration; Single dose; 45 minutes before test) has anti-anxiety effect in mouse model[4].
6-Hydroxyflavone (25-50 mg/kg; Intraperitoneal injection; 15 days) shows protective effect in Cisplatin (HY-17394) -induced nephrotoxicity rat model[5]. | Animal Model: | Male ICR mice (20-36 g)[4] | | Dosage: | 6, 12, 25, 50 and 100 mg/kg | | Administration: | Oral administration (p.o.); Single dose; 45 minutes before test | | Result: | Showed anti-anxiety effects on behavioral tests.
|
| Animal Model: | Cisplatin (HY-17394) treated male Sprague-Dawley rats (200-250 g)[5] | | Dosage: | 25 and 50 mg/kg | | Administration: | Intraperitoneal injection (i.p.); 15 days | | Result: | Significantly attenuated the Cisplatin associated detrimental changes in the body weight, and serum levels of creatinine and urea at both 25 mg/kg and 50 mg/kg.
Preserved the renal histoarchitecture from the toxicological influence of Cisplatin.
Reduced the Cisplatin-induced lipid peroxidation and corrected the renal antioxidant status.
|
|
|
|