| Identification | More | [Name]
SINENSETIN | [CAS]
2306-27-6 | [Synonyms]
SINENSETIN
Sinenstein
Orange flavonoids
Pedalitin permethyl ether
Sinensetin, 98%, from plant
Sinensetin, froM Citrus nobilis
3',4',5,6,7-PENTAMETHOXYFLAVONE
5,6,7,3',4'-PENTAMETHOXYFLAVONE
Sinensetin, 98%, from Citrus nobilis
Sinensetin (Pedalitin permethyl ether)
Sinensetin
3′,4′,5,6,7-Pentamethoxyflavone
5,6,7,3'',4''-PENTAMETHOXYFLAVONE WITH HPLC
6-Hydroxyluteolin 5,6,7,3′,4′-pentamethyl ether
2-(3,4-dimethoxyphenyl)-5,6,7-trimethoxy-chromone
2-(3,4-Dimethoxyphenyl)-5,6,7-trimethoxy-4H-chromen-4-one
2-(3,4-dimethoxyphenyl)-5,6,7-trimethoxy-1-benzopyran-4-one
2-(3,4-Dimethoxyphenyl)-5,6,7-trimethoxy-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 2-(3,4-diMethoxyphenyl)-5,6,7-triMethoxy- | [Molecular Formula]
C20H20O7 | [MDL Number]
MFCD00017421 | [Molecular Weight]
372.37 | [MOL File]
2306-27-6.mol |
| Chemical Properties | Back Directory | [Melting point ]
174-176°C | [Boiling point ]
547.8±50.0 °C(Predicted) | [density ]
1.244±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble3mg/mL, clear (warmed) | [form ]
powder | [color ]
white to beige | [BRN ]
345748 | [InChI]
1S/C20H20O7/c1-22-13-7-6-11(8-15(13)23-2)14-9-12(21)18-16(27-14)10-17(24-3)19(25-4)20(18)26-5/h6-10H,1-5H3 | [InChIKey]
LKMNXYDUQXAUCZ-UHFFFAOYSA-N | [SMILES]
O=C1C=C(C2=CC(OC)=C(OC)C=C2)OC3=C1C(OC)=C(OC)C(OC)=C3 | [LogP]
2.634 (est) | [CAS DataBase Reference]
2306-27-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
25 | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3 | [HS Code ]
29329990 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from citrus. | [Uses]
antiangiogenesis, antidiabetic | [Uses]
Sinensetin exhibits anti-fungal, anti-histamine activity; induce cell differentiation, inhibition of linoleic acid oxidation, inhibition of white blood cells in the human zona protein Interleukin -1-i
nduced expression of tissue factor. | [Uses]
Sinensetin, eupatorin, 3'-hydroxy-5,6,7,4'-tetramethoxyflavone and rosmarinic acid contents and antioxidative effect of Orthosiphon stamineus from Malaysia. | [Definition]
ChEBI: A pentamethoxyflavone that is flavone substituted by methoxy groups at positions 5, 6, 7, 3' and 4' respectively. | [General Description]
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG | [Biochem/physiol Actions]
Sinensetin is a citris flavonoid with anti-inflammatory and anti-proliferative activity. It has also been shown to enhance adipogenesis and lipolysis. | [in vivo]
Sinensetin (50 mg/kg, single dose, i.p.) has anti-inflammatory effects on carrageenan (HY-125474) induced paw inflammation in the mouse[5]. | Animal Model: | Carrageenan-induced paw edema in male C57BL/6 mice[5] | | Dosage: | 50 mg/kg, single dose | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Sloewd the volume increased of the carrageenan-treated paw at 6 h. |
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