| Identification | Back Directory | [Name]
Sodium danshensu | [CAS]
67920-52-9 | [Synonyms]
dium danshensu
Sodium danshensu
DANSHENSU SODIUM (RG)
Salvianic acid A sodium
(±)-DanShenSu sodium sal
Salvia natriuretic peptide
Sodium Danshensu 67920-52-9
Salvianic acid A sodium,HPLC≥98%
Sodium 3-(3,4-dihydroxyphenyl)lactate
Sodium 3-(3,4-dihydroxyphenyl)-DL-lactate
sodium D-(+)-β-(3,4-dihydroxyphenyl)lactate
Sodium DL-beta-(3,4-dihydroxyphenyl)lactate
3-(3',4'-Dihydroxyphenyl)lactic acid sodium salt
α,3,4-Trihydroxybenzenepropanoic acid sodium salt
sodium 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate
3,4-Dihydroxyphenyl-α-hydroxypropanoic acid sodium salt
Benzenepropanoic acid, a,3,4-trihydroxy-, sodium salt(1:1)
3,4-Dihydroxyphenyl-.alpha.-hydroxypropanoic acid sodiuM salt
Sodium 3-(3,4-dihydroxyphenyl)lactate, 98%, from Salvia miltiorrhiza Bge. | [EINECS(EC#)]
804-287-0 | [Molecular Formula]
C9H9O5.Na | [MDL Number]
MFCD09037393 | [MOL File]
67920-52-9.mol | [Molecular Weight]
220.155 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
H2O : 100 mg/mL (454.24 mM; Need ultrasonic)DMSO : 100 mg/mL (454.24 mM; Need ultrasonic) | [form ]
powder | [color ]
White-beige | [InChI]
InChI=1S/C9H10O5.Na.H/c10-6-2-1-5(3-7(6)11)4-8(12)9(13)14;;/h1-3,8,10-12H,4H2,(H,13,14);; | [InChIKey]
UPKQTJGQYNOELB-UHFFFAOYSA-N | [SMILES]
C(C1C=CC(O)=C(O)C=1)C(O)C(=O)O.[NaH] |
| Hazard Information | Back Directory | [Description]
Danshensu is a salvianolic acid and the major component of S. miltiorrhiza (Danshen) and has diverse biological activities.1,2,3,4 It reduces expression of the autophagy-associated proteins p62, LC3-II, and Beclin-1 and the apoptosis-related proteins Bax and caspase-3, prevents cardiomyocyte damage, and increases heart rate, coronary flow (CF), and left ventricular developed pressure (LVDP) in an isolated rat heart model of ischemia and reperfusion injury.1 Danshensu (60 mg/kg per day) reduces infarct size and improves left ventricular function in a rat model of myocardial infarction.2 It enhances radiation-induced tumor cell death in a Lewis lung carcinoma mouse xenograft model.3 Danshensu also decreases infarct volume, neuronal apoptosis, production of TNF-α, IL-1β, and IL-6, and superoxide dismutase (SOD) and glutathione peroxidase (GPx) activity in a rat model of cerebral ischemia and reperfusion injury.4 | [Chemical Properties]
White to light brown powder | [Uses]
Sodium Danshensu is exhibits protective effects on the excitotoxicity of monosodium glutamate in the late stage of pregnancy on developing mouse fetal brain. | [in vivo]
Salvianic acid A (3 or 10 mg/kg, p.o., once daily for 6 weeks) suppresses inflammatory reactions and inhibits oxidative stress in atherosclerosis (AS) rats induced by a high-fat diet, showing protective effects against atherosclerosis[5]. | Animal Model: | Atherosclerosis (AS) model induced by a high-fat diet in Sprague-Dawley rats (180-220 g)[4] | | Dosage: | 3 or 10 mg/kg | | Administration: | Oral gavage (p.o.), once daily for 6 weeks | | Result: | Inhibited atherosclerotic lesion progression and reduced aortic lipid deposition by 58.2% and 72.8% in high-fat diet-induced AS rats.
Improved lipid profiles by lowering triglyceri/brdes, total cholesterol, and LDL cholesterol while significantly increasing HDL cholesterol in AS rats.
Enhanced antioxidant enzyme activity, upregulated the Nrf2/HO-1 pathway, and reduced the expression of p47phox and p22phox.
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| [target]
Calcium Channel | Potassium Channel | Akt | GSK-3 | Bcl-2/Bax | PI3K | [References]
[1] GUANWEI FAN. Danshensu alleviates cardiac ischaemia/reperfusion injury by inhibiting autophagy and apoptosis via activation of mTOR signalling[J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2016, 20 10: 1908-1919. DOI: 10.1111/jcmm.12883
[2] YING YIN . Danshensu accelerates angiogenesis after myocardial infarction in rats and promotes the functions of endothelial progenitor cells through SDF-1α/CXCR4 axis[J]. European journal of pharmacology, 2017, 814: Pages 274-282. DOI: 10.1016/j.ejphar.2017.08.035
[3] HONG-YING CAO. Danshensu, a major water-soluble component of Salvia miltiorrhiza, enhances the radioresponse for Lewis Lung Carcinoma xenografts in mice.[J]. Oncology Letters, 2017, 13 2: 605-612. DOI: 10.3892/ol.2016.5508
[4] HANG XU. Synergistic neuroprotective effects of Danshensu and hydroxysafflor yellow A on cerebral ischemia-reperfusion injury in rats.[J]. Oncotarget, 2017, 8 70: 115434-115443. DOI: 10.18632/oncotarget.23272 |
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