| Identification | Back Directory | [Name]
3-(3,4-dihydroxyphenyl)-2-hydroxy-propanoic acid | [CAS]
23028-17-3 | [Synonyms]
(Rac)-Danshensu
Danshensu lactic acid
(Rac)-Salvianic acid A
α-Hydroxyhydrocaffeic acid
3,4-dihydroxyphenyllactic acid
3-(3,4-Dihydroxyphenyl)lactic acid
α,3,4-Trihydroxybenzenepropanoic acid
α,3,4-Trihydroxybenzenepropionic acid
Benzenepropanoic acid, α,3,4-trihydroxy-
alpha,3,4-Trihydroxy-benzenepropanoic acid
3,4-DIHYDROXYPHENYLLACTIC ACID SODIUM SALT 90%
2-Hydroxy-3-(3,4-dihydroxyphenyl)propanoic acid
2-Hydroxy-3-(3,4-dihydroxyphenyl)propionic acid
3-(3,4-Dihydroxyphenyl)-2-hydroxypropionic acid
3-(3,4-dihydroxyphenyl)-2-hydroxy-propanoic acid | [Molecular Formula]
C9H10O5 | [MOL File]
23028-17-3.mol | [Molecular Weight]
198.17 |
| Chemical Properties | Back Directory | [Boiling point ]
481.5±40.0 °C(Predicted) | [density ]
1.546±0.06 g/cm3 (20 ºC 760 Torr) | [form ]
Solid | [pka]
3.82±0.10(Predicted) | [color ]
Light yellow to yellow | [LogP]
0.045 (est) |
| Hazard Information | Back Directory | [Uses]
(Rac)-Salvianic acid A is the racemate of Salvianic acid A (HY-N1913). Salvianic acid A, an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research[1][2][3]. | [Definition]
ChEBI: 3-(3,4-dihydroxyphenyl)lactic acid is a 2-hydroxy monocarboxylic acid and a member of catechols. It is functionally related to a rac-lactic acid. It is a conjugate acid of a 3-(3,4-dihydroxyphenyl)lactate. | [References]
[1] Wei Wang, et al. Danshensu alleviates pseudo-typed SARS-CoV-2 induced mouse acute lung inflammation. Acta Pharmacol Sin. 2022 Apr;43(4):771-780. DOI:10.1038/s41401-021-00714-4
[2] V Bharath Kumar, et al. Sodium Danshensu Inhibits Oral Cancer Cell Migration and Invasion by Modulating p38 Signaling Pathway. Front Endocrinol (Lausanne). 2020 Sep 30:11:568436. DOI:10.3389/fendo.2020.568436
[3] Chen Yu, et al. Danshensu attenuates cisplatin-induced nephrotoxicity through activation of Nrf2 pathway and inhibition of NF-κB. Biomed Pharmacother. 2021 Oct:142:111995. DOI:10.1016/j.biopha.2021.111995 |
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