| Identification | Back Directory | [Name]
SUBSTANCE P (1-7) | [CAS]
68060-49-1 | [Synonyms]
RPKPQQF
1-7-Substance P
SUBSTANCE P (1-7)
SUBSTANCE P FRAGMENT 1-7
ARG-PRO-LYS-PRO-GLN-GLN-PHE
H-ARG-PRO-LYS-PRO-GLN-GLN-PHE-OH
SUBSTANCE P FRAGMENT 1-7SUBSTANCE
Substance P Fragment 1-7, ≥97% (HPLC)
L-Arg-L-Pro-L-Lys-L-Pro-L-Gln-L-Gln-L-Phe-OH
L-Arg-L-Pro-L-Lys-L-Pro-L-Glu(NH2)-L-Glu(NH2)-L-Phe-OH
PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2: PKPQQFFGLM-NH2
8-De-L-phenylalanine-9-deglycine-10-de-L-leucine-11-de-L-methioninamide-substance P
N5-(Diaminomethylene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanine | [Molecular Formula]
C41H65N13O10 | [MDL Number]
MFCD00076789 | [MOL File]
68060-49-1.mol | [Molecular Weight]
900.04 |
| Chemical Properties | Back Directory | [density ]
1.49±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
Soluble in DMSO | [form ]
powder | [pka]
3.49±0.10(Predicted) | [color ]
white | [Sequence]
Arg-Pro-Lys-Pro-Gln-Gln-Phe |
| Hazard Information | Back Directory | [Uses]
cell analysis | [Biological Activity]
Fragment th at gives depressor and bradycardic effects when applied to the nucleus tractus solitarius | [in vivo]
Substance P (1-7) is found to act as a very potent antagonist against the SP-induced responses and is formed locally in the nigra after SP injection. It is proposed that Substance P (1-7) is an endogenous modulator of SP actions[1]. Injection of low doses of Substance P (1-7) (1.0-4.0 pM simultaneously with SP or SP(5-11) (0.1 nM), reduce aversive behaviours induced by SP or SP(5- 11) significantly. These results indicate that SP(1-7) formed endogenously could modulate the actions of SP or SP(5-11) in the spinal cord[2]. | [storage]
Store at -20°C |
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