| Identification | Back Directory | [Name]
SUBSTANCE P (7-11) | [CAS]
51165-05-0 | [Synonyms]
FFGLM-NH2
PENTA-SUBSTANCE P
SUBSTANCE P (7-11)
Substance P 7-11(TFA)
PHE-PHE-GLY-LEU-MET-NH2
SUBSTANCE P FRAGMENT 7-11
H-PHE-PHE-GLY-LEU-MET-NH2
L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2
SUBSTANCE P FRAGMENT 7-11 ACETATE)
L-Phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-methioninamide
L-Methioninamide, L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-
ARG-PRO-LYS-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-OME: RPKPQQFFGLM-OME | [Molecular Formula]
C31H44N6O5S | [MDL Number]
MFCD00076801 | [MOL File]
51165-05-0.mol | [Molecular Weight]
612.78 |
| Chemical Properties | Back Directory | [Boiling point ]
1003.3±65.0 °C(Predicted) | [density ]
1?+-.0.06 g/cm3(Predicted) | [storage temp. ]
-15°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
13.26±0.46(Predicted) | [color ]
White to off-white | [Sequence]
Phe-Phe-Gly-Leu-Met-NH2 |
| Hazard Information | Back Directory | [Uses]
Substance P (7-11) is a C-terminal fragment of Substance P which can cause an increase in the intracellular calcium concentration. | [Definition]
ChEBI: L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2 is a pentapeptide composed of L-phenylalanine, L-phenylalanine, glycine, L-leucine, and L-methioninamide joined in sequence by peptide linkages. It is a C-terminal fragment of substance P. It is functionally related to a L-leucine, a L-methioninamide, a L-phenylalanine and a glycine. It is a conjugate base of a L-Phe-L-Phe-Gly-L-Leu-L-Met-NH2(1+). | [References]
[1] Halliday DA, et al. The substance P fragment SP-(7-11) increases prostaglandin E2, intracellular Ca2+ and collagenase production in bovine articular chondrocytes. Biochem J. 1993 May 15;292 ( Pt 1):57-62. DOI:10.1042/bj2920057 |
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