| Identification | More | [Name]
1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID | [CAS]
68077-26-9 | [Synonyms]
1-ETHYL-6-FLUORO-7-CHLORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACID
1-ETHYL-7-CHLORO-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXYLIC ACID
7-CHLORO-1,4-DIHYDRO-1-ETHYL-6-FLUORO-4-OXO-3-QUINOLINECARBOXYLIC ACID
7-CHLORO-1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO-3-QUINOLINE CARBOXYLIC ACID
7-CHLORO-1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXO QUINOLINE-3-CARBOXYLIC ACID
7-CHLORO-1-ETHYL-6-FLUORO-4-OXOHYDROQUINOLINE-3-CARBOXYLIC ACID
7-CHLORO-6-FLUORO-1-ETHYL-4-OXOQUINOLINE-3-CARBOXYLIC ACID
AKOS 1303
TIMTEC-BB SBB003042
7-Chloro-1-ethyl-6-fluoro-4-oxo-3-quinolinecarboxylicacid7-Chloro-1-ethyl-6-fluoro-4-oxo-3-quinolinecarboxylicacid
7-CHLORO-1,4-DIHYDRO-L-ETHYL-6-FLUORO-4-OXO-3-QUINOLINECARBOXYLIC ACID
7-CHLORO-1-ETHYL-6-FLUORO-4-OXOBYDROQUINOINE-3-CARBOXYLIC ACID
7-CHLORO-1-ETHYL-6-FLUORO-4-OXOHYDROQUINOLINE-3-CARBOXYLIC ACID 98%
7-CHLORO-1-ETHYL-6-FLUORO-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBO
1-ETHYL-6-FLUORO-7-CHLORO-1,4-DIHYDRO-4-OXO-3-QUINOLINECARBOXYLIC ACIDNORFLOXACIN
A mixture of: 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid 5-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid
1-Ethyl-1,4-dihydro-4-oxo-6-fluoro-7-chloroquinoline-3-carboxylic acid
7-Chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | [EINECS(EC#)]
421-280-4 | [Molecular Formula]
C12H9ClFNO3 | [MDL Number]
MFCD00792459 | [Molecular Weight]
269.66 | [MOL File]
68077-26-9.mol |
| Chemical Properties | Back Directory | [Appearance]
White powder | [Melting point ]
245°C | [Boiling point ]
437.9±45.0 °C(Predicted) | [density ]
1.3905 (estimate) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO (Slightly, Heated), Methanol (Slightly, Heated) | [form ]
neat | [pka]
-0.21±0.20(Predicted) | [color ]
White to Pale Yellow | [Major Application]
pharmaceutical (small molecule) | [InChI]
1S/C12H9ClFNO3/c1-2-15-5-7(12(17)18)11(16)6-3-9(14)8(13)4-10(6)15/h3-5H,2H2,1H3,(H,17,18)/p-1 | [InChIKey]
WNNSMMJBBOPPOT-UHFFFAOYSA-N | [SMILES]
Fc1cc2c(cc1Cl)N(C=C(C2=O)C(=O)[O-])CC | [CAS DataBase Reference]
68077-26-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H412 | [Precautionary statements ]
P273-P501 | [Risk Statements ]
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [HazardClass ]
IRRITANT | [HS Code ]
2933599550 |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Uses]
7-Chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid (Norfloxacin EP Impurity A) is a Norfloxacin intermediate. Norfloxacin EP Impurity A; Norfloxacin USP Related Compound A (7-Chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid). | [Uses]
Norfloxacin intermediate. | [Synthesis]
Ethyl 7-chloro-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate (2.75 g, 9.24 mmol) was used as a raw material and dissolved in 60 mL of methanol. Subsequently, a 1:1 solution of hydrochloric acid (31.5 mL, 189 mmol) was added. The reaction mixture was heated to reflux for 2 h. Upon completion of the reaction, a white solid precipitated. The solid product was collected by filtration and washed with plenty of water. Finally, the product was dried in a vacuum oven for 2 h to afford 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-carbonylquinoline-3-carboxylic acid (2.46 g, yield: 89.5%). | [References]
[1] Journal of Medicinal Chemistry, 2009, vol. 52, # 14, p. 4257 - 4265
[2] Liebigs Annalen der Chemie, 1987, p. 29 - 37
[3] Chemical Communications, 2018, vol. 54, # 15, p. 1869 - 1872
[4] Journal of Medicinal Chemistry, 1980, vol. 23, # 12, p. 1358 - 1363
[5] Patent: CN107445892, 2017, A. Location in patent: Paragraph 0016 |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
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Alfa Aesar
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400-6106006 |
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http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
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400-0056266 |
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www.energy-chemical.com |
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