| Identification | More | [Name]
D(-)Prolinol | [CAS]
68832-13-3 | [Synonyms]
(2R)-PYRROLIDIN-2-YLMETHANOL
(+)-D-PROLINOL
D(-)PROLINOL
D-PROLINOL
H-D-PROLINOL
H-D-PRO-OL
(R)-1-PYRROLIDIN-2-YL-METHANOL
(R)-(-)-2-(HYDROXYMETHYL)PYRROLIDINE
R-2-HYDROXYMETHYL-PYRROLIDINE
(R)-(-)-2-PYRROLIDINEMETHANOL
R-2-PYRROLIDINEMETHANOL
(R)-(-)-PROLINOL
(R)-PROLINOL
(R)-PYRROLIDINE-2-METHANOL
(R)-(-)-2-(Hydroxymethyl)pyrrolidine (R)-(-)-2-Pyrrolidinemethanol
(R)-(-)-PyrrolidinemethanolD-Prolinol
D-Pro-ol(oil)
2-Pyrrolidinemethanol, (2R)-
(R)-2-Hydroxymethylpyrrolidone
(R)-(-)-Prolinol, 98+% | [EINECS(EC#)]
629-147-4 | [Molecular Formula]
C5H11NO | [MDL Number]
MFCD00064321 | [Molecular Weight]
101.15 | [MOL File]
68832-13-3.mol |
| Questions And Answer | Back Directory | [Synthesis]
There are two main methods for the synthesis of D(-)Prolinol: (1) indirect reduction method: using D-proline as raw material, esterification and neutralization are performed, followed by reduction with NaBH4; (2) direct reduction method: D-proline is directly reduced with AlLiH4. The former is cumbersome and has a low yield (42.6%); the latter is demanding, requiring low-temperature ice bath addition, resulting in high cost and a dark product color. The authors used a reduction system of NaBH4 with added auxiliary I2 to directly reduce D-proline to D-proline (see figure below), which is low-cost, of good quality, stable, easy to operate, and readily industrialized.  |
| Chemical Properties | Back Directory | [Appearance]
Colorless to light yellow liqui | [alpha ]
-31 º (c=1, toluene) | [Boiling point ]
74-76 °C2 mm Hg(lit.)
| [density ]
1.036 g/mL at 20 °C(lit.)
| [refractive index ]
n20/D 1.485
| [Fp ]
187 °F
| [storage temp. ]
2-8°C
| [solubility ]
Chloroform (Slightly), Methanol (Slightly), Toluene (Slightly) | [form ]
Solution | [pka]
14.77±0.10(Predicted) | [color ]
Clear to slightly hazy colorless to amber | [Specific Gravity]
1.025 | [Optical Rotation]
[α]20/D 31°, c = 1 in toluene | [Sensitive ]
Air Sensitive | [BRN ]
1523669 | [InChIKey]
HVVNJUAVDAZWCB-RXMQYKEDSA-N | [CAS DataBase Reference]
68832-13-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S24/25:Avoid contact with skin and eyes . | [RIDADR ]
NA 1993 / PGIII | [WGK Germany ]
3
| [F ]
3-10-23 | [Hazard Note ]
Irritant/Air Sensitive | [HazardClass ]
IRRITANT | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless to light yellow liqui | [Uses]
(2R)-2-Pyrrolidinemethanol is used in the synthesis of potent selective 5-HT7 antagonists. | [Definition]
ChEBI: The D-enantiomer of prolinol. Metabolite observed in cancer metabolism. |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|