| Identification | Back Directory | [Name]
Eledoisin | [CAS]
69-25-0 | [Synonyms]
ELEDOSIN
ELEDOISIN
eledonepeptide
Eledosin Acetate
Eledoisin Acetate
PYR-PSKDAFIGLM-NH2
PYR-PRO-SER-LYS-ASP-ALA-PHE-ILE-GLY-LEU-MET-NH2
GLP-PRO-SER-LYS-ASP-ALA-PHE-ILE-GLY-LEU-MET-NH2
PGLU-PRO-SER-LYS-ASP-ALA-PHE-ILE-GLY-LEU-MET-NH2
5-Oxo-L-Pro-L-Pro-L-Ser-L-Lys-L-Asp-L-Ala-L-Phe-L-Ile-Gly-L-Leu-L-Met-NH2
5-oxo-l-prolyl-l-prolyl-l-seryl-l-lysyl-l-aspartyl-l-alanyl-l-phenylalanyl-l-isoleucylglycyl-l-leucyl-l-methioninamide | [EINECS(EC#)]
251-228-4 | [Molecular Formula]
C54H85N13O15S | [MDL Number]
MFCD00076373 | [MOL File]
69-25-0.mol | [Molecular Weight]
1188.4 |
| Chemical Properties | Back Directory | [Melting point ]
230 °C (decomp) | [Boiling point ]
1618.1±65.0 °C(Predicted) | [density ]
1.289±0.06 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
DMF: 15 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:20): 0.04 mg/ml | [form ]
A crystalline solid | [pka]
4.19±0.10(Predicted) | [color ]
White to off-white | [optical activity]
-4422 (95% Acetic Acid) | [Sequence]
{Glp}-Pro-Ser-Lys-Asp-Ala-Phe-Ile-Gly-Leu-Met-NH2 |
| Hazard Information | Back Directory | [Uses]
Eledoisin (Eledone peptide) is a specific agonist of NK2 and NK3 receptors. | [Definition]
ChEBI: Eledoisin is a peptide. | [in vivo]
Eledoisin (Eledone peptide; 0.1-1 nmol/kg) injected into rats produces a biphasic cardiovascular response that consists of an initial fall of systemic blood pressure (8-15 mm Hg) followed by a rise (20-22 mm Hg). Intracerebroventricular injection of Eledoisin produces an enhancement of grooming and scratching behavior in mice[2]. | [IC 50]
NK2; NK3 | [References]
[1] Lippe C, et al. Eledoisin and Kassinin, but not Enterokassinin, stimulate ion transport in frog skin. Peptides. 2004 Nov;25(11):1971-5. DOI:10.1016/j.peptides.2004.06.014
[2] Severini C, et al. The tachykinin peptide family. Pharmacol Rev. 2002 Jun;54(2):285-322. DOI:10.1124/pr.54.2.285 |
|
|