| Identification | Back Directory | [Name]
Pendulone | [CAS]
69359-09-7 | [Synonyms]
Pendulone
2,5-Cyclohexadiene-1,4-dione, 5-(3,4-dihydro-7-hydroxy-2H-1-benzopyran-3-yl)-2,3-dimethoxy- | [Molecular Formula]
C17H16O6 | [MDL Number]
MFCD28339351 | [MOL File]
69359-09-7.mol | [Molecular Weight]
316.31 |
| Hazard Information | Back Directory | [Uses]
Pendulone is a isoflavanquinone with good antiplasmodial activity with an IC50 of 7.0 μM. Pendulone also has antileishmanial, antibacterial and anticancer activity[1][2]. | [Definition]
ChEBI: Pendulone is an isoflavonoid. | [in vivo]
Pendulone shows potent anti-tumor-promoting activity for an in vivo two-stage carcinogenesis test of mouse skin using 7,12-dimethylbenz[a]-anthracene and TPA[3]. | [IC 50]
Plasmodium; Leishmania | [References]
[1] Qingxi Su, et al. Antiplasmodial Isoflavanes and Pterocarpans from Apoplanesia paniculata. Planta Med. 2015 Aug;81(12-13):1128-32. DOI:10.1055/s-0035-1546036
[2] Aziz A Rahman, et al. Antiparasitic and antimicrobial isoflavanquinones from Abrus schimperi. Nat Prod Commun. 2011 Nov;6(11):1645-50. PMID:22224279
[3] T Konoshima, et al. Anti-tumor promoting activities of isoflavonoids from Wistaria brachybotrys. Biol Pharm Bull. 1997 Aug;20(8):865-8. DOI:10.1248/bpb.20.865 |
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