| Identification | More | [Name]
Sulbactam sodium | [CAS]
69388-84-7 | [Synonyms]
sodium (2s-cis)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide
SODIUM SULBACTAM
SULBACTAM SODIUM
SULBACTAM SODIUM SALT
4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,3,3-dimethyl-7-oxo-,4,4-d
cp45899sodiumsalt
penicillanicacid1,1-dioxidesodiumsalt
penicillanicaciddioxidesodiumsalt
penicillanicacidsulfonesodiumsalt
sodium1,1-dioxopenicillanate
sodiumpenicillanate1,1-dioxide
sodiumsalt,(2s-cis)-ioxid
(2S-cis)-3,3-Dimethyl-7-oxo-4-thia-1-azabicyclo[3,2,0]heptane-2-carboxylic acid 4,4-dioxide sodium salt
Sulbatam Sodium
sulbacyam sodium
AMPICILLIN SODIUM AND SULBACTAM SODIUM 2:1
CP-45899-2
Penicillanic acid 4,4-dioxide sodium salt | [EINECS(EC#)]
273-984-4 | [Molecular Formula]
C8H10NNaO5S | [MDL Number]
MFCD01750374 | [Molecular Weight]
255.22 | [MOL File]
69388-84-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
>230°C (dec.) | [storage temp. ]
-20°C Freezer, Under Inert Atmosphere | [solubility ]
Freely soluble in water, sparingly soluble in ethyl acetate, very slightly soluble in ethanol (96 per cent). It is freely soluble in dilute acids. | [form ]
neat | [color ]
White | [InChIKey]
NKZMPZCWBSWAOX-IBTYICNHSA-M | [CAS DataBase Reference]
69388-84-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R42/43:May cause sensitization by inhalation and skin contact . | [Safety Statements ]
S22:Do not breathe dust .
S24:Avoid contact with skin .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [HS Code ]
29349990 | [Toxicity]
LD50 ivn-rat: 6500 mg/kg NKRZAZ 32(Suppl 4),97,84 |
| Hazard Information | Back Directory | [Description]
Sulbactam sodium is a parenterally-active, β-lactamase inhibitor recently
introduced as a 1: 1 combination product with cefoperazone. Like clavulanic acid,
the first agent of this type to b e introduced, sulbactam enhances the effectiveness
of β-lactam antibiotics against resistant strains. | [Chemical Properties]
White Solid | [Originator]
Pfizer (USA) | [Uses]
A semi-synthetic β-lactamase inhibitor. It is used in combination with β-lactam antibiotics as antibacterial. | [Definition]
ChEBI:Sulbactam sodium is an organooxygen compound and an organonitrogen compound. It is functionally related to an alpha-amino acid. | [Manufacturing Process]
Sulbactam sodium is semi-synthetic antibiotic of penicillinic group. Start
material for it's synthesis is 6-aminopenicillanic acid. First 6-aminopenicillanic
acid was isolated in 1957 year from benzylpenicilline as resalt of treating of it
by penicillinaze. Benzylpenicilline is produced by microorganism of genus
Streptomyces.
Further, 6-aminopenicillanic acid reacted with bromine, hydrochloric acid and
NaNO2. As a result the 6,6-dibromopenicillanic acid was obtained.
6,6-Dibromopenicillanic acid was oxidized by KMnO4, to give 6,6-dibromo-1,1-The 6,6-dibromo-1,1-dioxopenicillanic acid in presence of Fe was converted to
the 1,1-dioxopenicillanic acid (sulbactam acid). The sulbactam acid was
treated by sodium 2-ethylhexanoate and crude sulbactam sodium was
obtained. | [Brand name]
SULPERAZONE | [Therapeutic Function]
Beta-lactamase inhibitor | [Safety Profile]
Poison by intravenous route. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and SOx | [storage]
Store at -20°C, protect from light, stored under nitrogen |
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