| Identification | Back Directory | [Name]
UAMC 00039 dihydrochloride | [CAS]
697797-51-6 | [Synonyms]
UAMC00039
UAMC00039 2HCl
UAMC 00039;UAMC-00039
UAMC 0039 (hydrochloride)
UAMC 00039 dihydrochloride
UAMC00039dihydrochloride, >98%
UAMC00039 DIHYDROCHLORIDE, >98%
(2S)-2-Amino-4-[[(4-chlorophenyl)methyl]amino]-1-(1-piperidinyl)-1-butanone dihydrochloride | [Molecular Formula]
C16H25Cl2N3O | [MDL Number]
MFCD27937768 | [MOL File]
697797-51-6.mol | [Molecular Weight]
346.3 |
| Chemical Properties | Back Directory | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [solubility ]
DMF: 2 mg/mL; DMSO: 14 mg/mL; Ethanol: 5 mg/mL; PBS (pH 7.2): 10 mg/mL | [form ]
Powder | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
UAMC 0039 is a potent inhibitor of dipeptidyl peptidase 2 (DPP-2; IC50 = 0.48 nM). It also inhibits DPP-4 (IC50 = 165 μM). DPP-2 is thought to be involved in degradation of collagen, substance P, and some proline-containing neuropeptides. | [Uses]
UAMC 00039 Dihydrochloride is a highly potent and selective dipeptidase II inhibitor. | [in vivo]
A dose dependent inhibition of DPPII but not of DPPIV is observed in the peripheral organs of both the rats and the mice (after oral administration) and the rabbits (after IV administration). UAMC00039 tested orally at 2 mg/kg does not cause signs of acute toxicity and does not cause any significant changes in the following functions that are evaluated: general behaviour, body temperature, respiration, bleeding time, blood pressure, urine volume, liver function, fasting glucose and gastrointestinal parameters like acidity, motility and irritation[1]. | [storage]
Store at -20°C | [References]
[1] KRISTEL SENTEN. γ-Amino-Substituted Analogues of 1-[(S)-2,4-Diaminobutanoyl]piperidine as Highly Potent and Selective Dipeptidyl Peptidase II Inhibitors[J]. Journal of Medicinal Chemistry, 2004, 47 11: 2906-2916. DOI: 10.1021/jm031122f
[2] K J ANDERSEN J K M. Lysosomal heterogeneity of dipeptidyl peptidase II active on collagen-related peptides.[J]. Renal physiology and biochemistry, 1989, 12 1: 32-40. DOI: 10.1159/000173177
[3] ROLF MENTLEIN Gemot S. Purification of Two Dipeptidyl Aminopeptidases II from Rat Brain and Their Action on Proline-Containing Neuropeptides[J]. Journal of Neurochemistry, 1989, 52 4: 1284-1293. DOI: 10.1111/j.1471-4159.1989.tb01877.x |
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Twochem Co.Ltd.
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021-58111628 15800915896 |
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cn.twochem.com |
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