| Identification | Back Directory | [Name]
UAMC-3203 hydrochloride | [CAS]
2271358-65-5 | [Synonyms]
UAMC-3203HCl
UAMC-3203 hydrochloride | [Molecular Formula]
C25H38ClN5O2S | [MDL Number]
MFCD32062758 | [MOL File]
2271358-65-5.mol | [Molecular Weight]
508.12 |
| Chemical Properties | Back Directory | [storage temp. ]
4°C, away from moisture and light | [solubility ]
DMF: 10mg/mL; DMSO: 25mg/mL; DMSO:PBS (pH 7.2) (1:3): 0.25mg/mL | [form ]
A crystalline solid | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
UAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM[1]. | [in vivo]
No toxicity is observed in mice after repeated injections of UAMC-3203 (20 μmol/kg; injected intraperitoneally; daily, over a period of 4 weeks)[1]. | Animal Model: | Wild type mice derived from a Gpx4 fl/fl breeding[1] | | Dosage: | 20 μmol/kg | | Administration: | Injected intraperitoneally; daily, over a period of 4 weeks | | Result: | No toxicity was observed. |
| [References]
[1] Devisscher L, et al. Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy. J Med Chem. 2018 Nov 21;61(22):10126-10140. DOI:10.1021/acs.jmedchem.8b01299 |
|
|