| Identification | Back Directory | [Name]
(5E,9Z,11Z,14Z)-8-hydroxyicosa-5,9,11,14-tetraenoic acid | [CAS]
70968-93-3 | [Synonyms]
NLUNAYAEIJYXRB-HEJOTXCHSA-N
(5E,9Z,11Z,14Z)-8-hydroxyicosa-5,9,11,14-tetraenoic acid | [Molecular Formula]
C20H32O3 | [MOL File]
70968-93-3.mol | [Molecular Weight]
320.47 |
| Chemical Properties | Back Directory | [Boiling point ]
471.1±45.0 °C(Predicted) | [density ]
0.984±0.06 g/cm3(Predicted) | [solubility ]
0.1 M Na2CO3: 2 mg/ml
DMF: Miscible
DMSO: Miscible
Ethanol: MisciblePBS pH 7.2: 0.8 mg/ml | [form ]
Liquid | [pka]
4.75±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
(±)8-HETE is one of the six monohydroxy fatty acids produced by the non-enzymatic oxidation of Arachidonic acid (HY-109590). The biological activity of (±)8-HETE is likely to resemble that of its constituent enantiomers (8(R)-HETE and 8(S)-HETE). | [Definition]
ChEBI: 8-HETE is an HETE having a 8-hydroxy group and (5Z)-, (9E)-, (11Z)- and (14Z)-double bonds. It has a role as a mouse metabolite. It is a conjugate acid of an 8-HETE(1-). | [References]
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[3] YILIN PANG . LC−MS/MS-based arachidonic acid metabolomics in acute spinal cord injury reveals the upregulation of 5-LOX and COX-2 products[J]. Free Radical Biology and Medicine, 2022, 193: Pages 363-372. DOI: 10.1016/j.freeradbiomed.2022.10.303
[4] ANNE-SOPHIE ARCHAMBAULT. High levels of eicosanoids and docosanoids in the lungs of intubated COVID-19 patients[J]. FASEB Journal, 2021, 35 6. DOI: 10.1096/fj.202100540r
[5] CARLOS ARTÉRIO SORGI. Comprehensive high-resolution multiple-reaction monitoring mass spectrometry for targeted eicosanoid assays[J]. Scientific Data, 2018, 5 1: 1-12. DOI: 10.1038/sdata.2018.167
[6] RYOHEI AOYAGI. Comprehensive analyses of oxidized phospholipids using a measured MS/MS spectra library.[J]. Journal of Lipid Research, 2017, 58 11: 2229-2237. DOI: 10.1194/jlr.d077123
[7] ALWENA H MORGAN. Quantitative assays for esterified oxylipins generated by immune cells[J]. Nature Protocols, 2010, 5 12: 1919-1931. DOI: 10.1038/nprot.2010.162 |
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