| Identification | Back Directory | [Name]
GCZRCCHPLVMMJE-RLZWZWKOSA-N | [CAS]
71030-38-1 | [Synonyms]
GCZRCCHPLVMMJE-RLZWZWKOSA-N 5,8,12,14-Eicosatetraenoic acid, 11-hydroxy-, (5Z,8Z,12E,14Z)- | [Molecular Formula]
C20H32O3 | [MDL Number]
MFCD00065825 | [MOL File]
71030-38-1.mol | [Molecular Weight]
320.47 |
| Hazard Information | Back Directory | [Uses]
1,2-Di-O-hexadecyl-sn-glycero-3-phosphatidylethanolamine is an ester product. | [Definition]
ChEBI: 11-HETE is a HETE that is (5Z,8Z,12E,14Z)-icosa-5,8,12,14-tetraenoic acid substituted at position 11 by a hydroxy group. It has a role as a mouse metabolite. It is functionally related to an icosa-5,8,12,14-tetraenoic acid. It is a conjugate acid of an 11-HETE(1-). | [References]
[1] WILLIAM S. POWELL Joshua R. Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid[J]. Biochimica et biophysica acta. Molecular and cell biology of lipids, 2015, 1851 4: Pages 340-355. DOI: 10.1016/j.bbalip.2014.10.008 [2] PRISCILLA BENTO MATOS CRUZ DEROGIS Sayuri M Adriano B Chaves Fillho. Characterization of Hydroxy and Hydroperoxy Polyunsaturated Fatty Acids by Mass Spectrometry.[J]. Advances in experimental medicine and biology, 2019, 1127: 21-35. DOI: 10.1007/978-3-030-11488-6_2 [3] GUIDO D.M. Mathews W R Mckenna R. Quantitation of Hydroperoxy-Eicosatetraenoic Acids and Hydroxy-Eicosatetraenoic Acids as Indicators of Lipid Peroxidation Using Gas Chromatography-Mass Spectrometry[J]. Analytical biochemistry, 1993, 209 1: Pages 123-129. DOI: 10.1006/abio.1993.1091 [4] R.D.R. CAMP. The identification of hydroxy fatty acids in psoriatic skin[J]. Prostaglandins, 1983, 26 3: Pages 431-447. DOI: 10.1016/0090-6980(83)90178-8 [5] EMMA WADDINGTON . Identification and Quantitation of Unique Fatty Acid Oxidation Products in Human Atherosclerotic Plaque Using High-Performance Liquid Chromatography[J]. Analytical biochemistry, 2001, 292 2: Pages 234-244. DOI: 10.1006/abio.2001.5075 [6] DONG CHENG. MGAT2 inhibitor decreases liver fibrosis and inflammation in murine NASH models and reduces body weight in human adults with obesity.[J]. Cell metabolism, 2022, 34 11: 1732-1748.e5. DOI: 10.1016/j.cmet.2022.10.007 [7] YILIN PANG . LC−MS/MS-based arachidonic acid metabolomics in acute spinal cord injury reveals the upregulation of 5-LOX and COX-2 products[J]. Free Radical Biology and Medicine, 2022, 193: Pages 363-372. DOI: 10.1016/j.freeradbiomed.2022.10.303 [8] ANNE-SOPHIE ARCHAMBAULT. High levels of eicosanoids and docosanoids in the lungs of intubated COVID-19 patients[J]. FASEB Journal, 2021, 35 6. DOI: 10.1096/fj.202100540r [9] DAVID MERIWETHER. Apolipoprotein A-I mimetics mitigate intestinal inflammation in COX2-dependent inflammatory bowel disease model.[J]. Journal of Clinical Investigation, 2019, 129 9: 3670-3685. DOI: 10.1172/jci123700 [10] CARLOS ARTÉRIO SORGI. Comprehensive high-resolution multiple-reaction monitoring mass spectrometry for targeted eicosanoid assays[J]. Scientific Data, 2018, 5 1: 1-12. DOI: 10.1038/sdata.2018.167 [11] JAMIE L LAHVIC. Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 37: 9252-9257. DOI: 10.1073/pnas.1806077115 [12] SANDRA GOUVEIA-FIGUEIRA. Characterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase Inhibitor.[J]. PLoS ONE, 2015: e0139212. DOI: 10.1371/journal.pone.0139212 [13] ALWENA H MORGAN. Quantitative assays for esterified oxylipins generated by immune cells[J]. Nature Protocols, 2010, 5 12: 1919-1931. DOI: 10.1038/nprot.2010.162 |
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