| Identification | Back Directory | [Name]
MRS 2578 | [CAS]
711019-86-2 | [Synonyms]
CS-1109
MRS 2578
MRS-2578; MRS2578
MRS 2578 USP/EP/BP
MRS 2578 >=95% (HPLC)
MRS 2578;MRS-2578; MRS2578
1,4-DI[3-(3-ISOTHIOCYANATOPHENYL)THIOUREIDO]BUTANE
N,N''-1,4-BUTANEDIYLBIS[N'-(3-ISOTHIOCYANATOPHENYL)THIOUREA]
1,1'-(Butane-1,4-diyl)bis(3-(3-isothiocyanatophenyl)thiourea)
Thiourea, N,N''-1,4-butanediylbis[N'-(3-isothiocyanatophenyl)-
N',N'''-butane-1,4-diylbis[1-(3-isothiocyanatophenyl)(thiourea)]
Thiourea, N,N''-1,4-butanediylbis[N'-(3-isothiocyanatophenyl)- (9CI) | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C20H20N6S4 | [MDL Number]
MFCD07370141 | [MOL File]
711019-86-2.mol | [Molecular Weight]
472.67 |
| Chemical Properties | Back Directory | [Melting point ]
170 - 173°C | [Boiling point ]
652.7±65.0 °C(Predicted) | [density ]
1.31 | [storage temp. ]
2-8°C
| [solubility ]
DMSO: ~17 mg/mL
| [form ]
solid
| [pka]
11.80±0.70(Predicted) | [color ]
white
| [InChIKey]
QOHNRGHTJPFMSL-UHFFFAOYSA-N |
| Hazard Information | Back Directory | [Description]
MRS2578 is an antagonist of the purinergic P2Y6 receptor (IC50s = 37 and 98 nM for human and rat receptors, respectively). It is without effect at other purinergic receptors. MRS2578 is used to study the cellular and physiological roles of P2Y6. | [Uses]
MRS 2578 has been used an antagonist of purinoceptor P2Y6:
- to study the role of purinergic receptor in Up4A-induced relaxation in coronary small arteries from swine
- in P. aeruginosa infected mice to test its effect on the inflammatory responses
- to test its inhibition on neutrophil extracellular traps and monosodium urate (MSU) crystals formation in polymorphonuclear leukocytes
| [Uses]
MRS 2578 is a selective P2Y66?receptor antagonist. | [Biological Activity]
Selective antagonist of P2Y 6 nucleotide receptors; IC 50 values are 37 and 98 nM at human and rat P2Y 6 receptors respectively. Displays no activity at P2Y 1 , P2Y 2 , P2Y 4 and P2Y 11 receptors (IC 50 > 10 μ M). Inhibits agonist-induced cardiomyocyte contraction and UDP-induced phagocytosis. | [Biochem/physiol Actions]
MRS 2578 elicits cytoprotective functionality in neuroblastoma cells and prevents dopaminergic neuron death under in vitro and in vivo conditions. It also protects microglia by delaying lipopolysaccharide-induced death. | [storage]
Store at 2-8°C | [References]
[1] mamedova l k, joshi b v, gao z g, et al. diisothiocyanate derivatives as potent, insurmountable antagonists of p2y6 nucleotide receptors[j]. biochemical pharmacology, 2004, 67(9): 1763-1770. |
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| Company Name: |
NCE Biomedical Co.,Ltd.
|
| Tel: |
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15748/0.htm |
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