| Identification | Back Directory | [Name]
5-CHLORO-4-METHYL-2-NITROANILINE | [CAS]
7149-80-6 | [Synonyms]
NSC 72334
TIMTEC-BB SBB003703
5-CHLORO-2-NITRO-P-TOLUIDINE
4-Amino-2-chloro-5-nitrotoluene
5-CHLORO-4-METHYL-2-NITROANILINE
5-Chloro-4-methyl-2-nitroaniline,96%
5-Chloro-4-methyl-2-nitroaniline, 95+%
5-Chloro-4-methyl-1-amino-2-nitrobenzene | [Molecular Formula]
C7H7ClN2O2 | [MDL Number]
MFCD00034066 | [MOL File]
7149-80-6.mol | [Molecular Weight]
186.6 |
| Chemical Properties | Back Directory | [Appearance]
orange-brown crystalline powder | [Melting point ]
159-163 °C
| [Boiling point ]
339.3±37.0 °C(Predicted) | [density ]
1.415±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
Crystalline Powder | [pka]
-0.79±0.25(Predicted) | [color ]
Orange-brown |
| Hazard Information | Back Directory | [Chemical Properties]
orange-brown crystalline powder | [Synthesis]
(b) Preparation of the intermediate compound 5-chloro-4-methyl-2-nitroaniline: Sodium ethoxide (8.27 g, 45.9 mmol) was dissolved in ethanol (10 mL) to prepare a sodium ethoxide solution. The solution was slowly added to a solution of ethanol (10 mL) containing N-(2-nitro-4-methyl-5-chlorophenyl)acetamide (7.0 g, 30.6 mmol) with stirring at room temperature. After 1 hour of reaction, the reaction mixture was poured into water (100 mL) and precipitate was precipitated. The precipitate was collected by filtration and washed with a mixture of isopropanol and n-hexane (1:3, 10 mL) followed by n-hexane (10 mL) to give 5.71 g (85% yield) of 5-chloro-4-methyl-2-nitroaniline. Mass spectrometry (MS) showed a m/z of 187.0 (M + 1). | [References]
[1] Patent: WO2010/19208, 2010, A1. Location in patent: Page/Page column 167-168
[2] Journal of Medicinal Chemistry, 1992, vol. 35, # 23, p. 4455 - 4463
[3] Journal of Heterocyclic Chemistry, 1981, vol. 18, p. 1635 - 1636
[4] Patent: WO2011/23812, 2011, A1. Location in patent: Page/Page column 164 |
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