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79622-59-6

79622-59-6 Structure

79622-59-6 Structure
IdentificationMore
[Name]

Fluazinam
[CAS]

79622-59-6
[Synonyms]

3-chloro-n-(3-chloro-2,6-dinitro-4-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-2-pyridinamine
3-CHLORO-N-(3-CHLORO-2,6-DINITRO-4-TRIFLUOROMETHYLPHENYL)-5-TRIFLUOROMETHYL-2-PYRIDYLAMINE
3-CHLORO-N-(3-CHLORO-5-TRIFLUOROMETHYL-2-PYRIDYL)-ALPHA,ALPHA,ALPHA-TRIFLUORO-2,6-DINITRO-P-TOLUIDINE
FLUAZINAM
FROWNCIDE
SHIRLAN
3-chloro-n-(3-chloro-2,6-dinitro-4-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-2-pyridinamin
3-chloro-n-(3-chloro-2,6-dinitro-4-(trifluoromethyl)phenyl)-5-2-pyridinamin
6-dinitro-4-trifluoromethylphenyl)-5-trifluoromethyl-3-chloro-n-(5-chloro-
asc66825
asc67178
ikf1216
pp192
shirlan(zeneca)
shirlanflow
3-chloro-N-(3-chloro-5-trifluoromethyl-2-pyridyl)-α,α,α-trifluor-2,6-dinitro-p-toluidine
fluaziname
FLUAZINAM SOLUTION
3-Chloro-N-(3-chloro-5-trifluoromethyl-2-pyridyl)-α,α,α-trifluoro-2,6-dinitro-p-toluidine
2-Pyridinamine, 3-chloro-N-3-chloro-2,6-dinitro-4-(trifluoromethyl)phenyl-5-(trifluoromethyl)-
[EINECS(EC#)]

200-835-2
[Molecular Formula]

C13H4Cl2F6N4O4
[MDL Number]

MFCD00214168
[Molecular Weight]

465.09
[MOL File]

79622-59-6.mol
Chemical PropertiesBack Directory
[Melting point ]

100-102°
[Boiling point ]

376.1±42.0 °C(Predicted)
[density ]

1.766±0.06 g/cm3(Predicted)
[vapor pressure ]

1.5 x 10-3 Pa (25 °C)
[Fp ]

2 °C
[storage temp. ]

2-8°C
[solubility ]

DMF:25.0(Max Conc. mg/mL);53.75(Max Conc. mM)
DMSO:25.0(Max Conc. mg/mL);53.75(Max Conc. mM)
Ethanol:15.0(Max Conc. mg/mL);32.25(Max Conc. mM)
PBS (pH: 7.2):0.25(Max Conc. mg/mL);0.54(Max Conc. mM)
[form ]

neat
[pka]

7.11(at 25℃)
[Water Solubility ]

1.7 mg l-1 (25 °C)
[color ]

Light yellow to Amber to Dark green
[Merck ]

14,4117
[BRN ]

4772672
[Contact allergens]

Fluazinam is a pesticide with a broad spectrum of anti fungal activity. It caused sensitization in employees in the tulip bulb industry and in farmers. Fluazinam induced contact dermatitis in a worker in a plant where it was manufactured.
[InChIKey]

UZCGKGPEKUCDTF-UHFFFAOYSA-N
[LogP]

3.560
[CAS DataBase Reference]

79622-59-6(CAS DataBase Reference)
[EPA Substance Registry System]

79622-59-6(EPA Substance)
Hazard InformationBack Directory
[Chemical Properties]

yellow crystal mp 115 ~ 117°C
[Uses]

Fluazinam is a broad spectrum fungicide. Fluazinam is commonly used for control of Sclerotinia blight and other soilborne pathogens of peanut as well for the control of potato blight.
[Definition]

ChEBI: A member of the class of aminopyridines that is 2-amino-5-(trifluoromethyl)pyridine in which one of the amino hydrogens is replaced by a 3-chloro-2,6-dinitro-4-(trifluoromethyl)phenyl group. A fungicide used to control grey mould, downy mildew and other fu gal pathogens.
[Uses]

Agricultural fungicide.
[Hazard]

Moderately toxic by ingestion and inhalation. A reproductive hazard.
[General Description]

Fluazinam is a 2,6-dinitroaniline protectant fungicide, which belongs to the pyridinamine group. It can mostly find applications in agriculture.
[Agricultural Uses]

Fungicide: Used to control Sclerotinia blight on peanuts and late blight and white mold on potatoes.
[Trade name]

FLUAZINAM 50 WP®; FROWNCIDE®; IKF-1216®; ICIA-192®; OMEGA; PP-192®; SHIRLAN®
[Metabolic pathway]

Fluazinam may typically be applied to crops of potatoes using up to 10 applications each of 150 g ha-1. Routes of degradation involve ring hydroxylation in aerobic soils and reduction of the nitro groups in flooded soils. A large amount of unextractable residue was observed. In potatoes and rats, important reactions involve the reduction of nitro groups and the formation of conjugates. In plants, the trifluoromethyl substituents are hydrolysed to carboxylic acid groups. Most of the information presented below was taken from an evaluation of the fungicide published by the UK Pesticide Safety Directorate (PSD, 1994).
[storage]

Store at -20°C
[Degradation]

Fluazinam is stable to acid, alkali and heat (PM). The DT50 values for hydrolysis in buffer solutions held in the dark at 22 °C were 42 and 5.6 days at pH 7 and 9, respectively. There was no appreciable hydrolysis at pH 5. The major reaction involved hydrolysis of a trifluoromethyl group to give the nicotinic acid derivative (2). The DT50 values of fluazinam in buffer solutions exposed to natural sunlight were in the range 2-3 days. Up to 11 products were separated but only the major product formed at pH 9, the nicotinic acid derivative (2), was characterised (PED, 1994).
Safety DataBack Directory
[Hazard Codes ]

T;N,N,T,Xn,F
[Risk Statements ]

R23:Toxic by inhalation.
R41:Risk of serious damage to eyes.
R43:May cause sensitization by skin contact.
R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R36:Irritating to the eyes.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R11:Highly Flammable.
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S60:This material and/or its container must be disposed of as hazardous waste .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S36/37:Wear suitable protective clothing and gloves .
S16:Keep away from sources of ignition-No smoking .
[RIDADR ]

UN 2811
[WGK Germany ]

3
[RTECS ]

UR8085000
[HazardClass ]

6.1
[PackingGroup ]

II
[HS Code ]

29333990
[Safety Profile]

Moderately toxic by ingestion and inhalation. Experimental reproductive effects. When heated to decomposition it emits toxic vapors of NOx, F-, and Cl-.
[Hazardous Substances Data]

79622-59-6(Hazardous Substances Data)
Raw materials And Preparation ProductsBack Directory
[Raw materials]

3-Chloro-5-(trifluoromethyl)pyridin-2-amine
Questions And AnswerBack Directory
[Description]

Fluazinam is a protective broad-spectrum contact fungicide registered for agricultural use to control various soil-borne fungal pathogens on a variety of crops, such as peanuts, potatoes, beans, etc. It can be applied as a foliar spray or soil treatment, which is effective against a number of diseases caused by pathogenic fungi such as gray mold, downy mildew, melanose, scab, alternaria blotch, clubroot, sclerotinia blight, white root rot, violet root rot. Besides, it shows acaricidal property, which can fight against mites in citrus.
However, as a protective agent, fluazinam is neither systemic or curative, which functions by inhibiting spore germination and spore growth, and also the development of infection structures, thereby giving it protective action with a good residual effect. The anti-fungal property of fluazinam acts by disrupting the energy production of the fungus at multiple sites and therefore preventing resistance.
[Toxicology & Ecotoxicology]

Rat LD50 (oral) :4,500 mg/kg (m), 4,100 mg/kg (f)
Rat LD50 (dermal) :> 2,000 mg/kg bw (m/f)
Rat LC50 (inhalation) :> 1.1 mg/L (m/f)
Skin irritation :mild irritant (rabbit)
Eye irritation :irritant (rabbit)
Skin sensitization :sensitizer (guinea pig)
Avian LD50 (acute oral) :> 4,190 mg/kg (mallard duck, m/f)
Avian LD50 (acute oral) :> 1,782 mg/kg (quail, m/f)
Fish LC50 :0.11 mg/L (rainbow trout, 96h)
Bee LD50 (oral) :> 100 μg/bee
Bee LD50 (contact) :> 100 μg/bee
Daphnia magna EC50 :0.19 mg/L (48 h)
[Environmental Fate]

Soil
Half-life- Aerobic = 132 days
Adsorption - Low mobility with Koc values ranged from 1705-2316
Persistence- Total fluazinam residues (fluazinam and its transformation products) are persistent in most environments and are likely to reach aquatic media through runoff. Fluazinam has the potential to bioaccumulate in fish.
Water
Half-life via hydrolysis - Stable at pH 5; 42 days at pH 7; and 6 days at pH 9
Surface water - Fluazinam and its transformation products are moderately persistent and may present concerns for transport to surface water by spray drift or runoff (especially in soils with low organic content)
Groundwater - Fluazinam should not leach substantially to groundwater.
Air
Volatilization- Fluazinam has a low vapor pressure 1.73 x 10-7 mm Hg and is not likely to substantially volatilize.
Degradates
Fluazinam may photolyze relatively rapidly in water (2.5 days) to form a tricyclic compound (G-504). Degradates were included in the drinking water risk assessment. The total fluazinam residues are persistent in most environments and are likely to reach aquatic media as a totality through runoff. The total residues may reach adjacent water bodies via runoff events and may be persistent.
Label use requirements are designed to mitigate related risk concerns
[References]

https://en.wikipedia.org/wiki/Fluazinam
http://www.agchemaccess.com/Fluazinam
http://www.galchimia.com/chemical-catalog/pesticide-impurities-and-metabolites/fluazinam-standard/
http://sitem.herts.ac.uk/aeru/ppdb/en/Reports/325.htm
Spectrum DetailBack Directory
[Spectrum Detail]

Fluazinam(79622-59-6)MS
Fluazinam(79622-59-6)1HNMR
Fluazinam(79622-59-6)13CNMR
Fluazinam(79622-59-6)IR1
Fluazinam(79622-59-6)IR2
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

79622-59-6(sigmaaldrich)
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