| Identification | More | [Name]
2-Amino-5-chlorobenzophenone | [CAS]
719-59-5 | [Synonyms]
2-AMINO-5-CHLOROBENZOPHENONE
(2-AMINO-5-CHLOROPHENYL)(PHENYL)METHANONE
4-CHLORO-2-BENZOYLANILINE
5-CHLORO-2-AMINOBENZOPHENONE
ACB
IFLAB-BB F1386-0355
LABOTEST-BB LT00259286
TIMTEC-BB SBB003271
(2-amino-5-chlorophenyl)phenyl-methanon
2-Amino-5-chlorbenzophenon
2-Amino-5-chlorbenzophenone
2-Amino-5-chlorodiphenylone
2-Benzoyl-4-chloroaniline
Methanone, (2-amino-5-chlorophenyl)phenyl-
2-Amino-5-chlorobenophenone
2-AMINO-5-CHLOROBENZOPHENONE 98%
2-Amino-5-chloro
2--5-
2-Amino-5-chlorobenzophenone ( for ALPRAZOLAM)
2-Amino-5-chlorobenzophenone, 98+% | [EINECS(EC#)]
211-949-7 | [Molecular Formula]
C13H10ClNO | [MDL Number]
MFCD00007839 | [Molecular Weight]
231.68 | [MOL File]
719-59-5.mol |
| Chemical Properties | Back Directory | [Appearance]
yellow powder | [Melting point ]
96-98 °C (lit.) | [Boiling point ]
207 °C
| [density ]
1.33 | [vapor pressure ]
0-1Pa at 20-25℃ | [refractive index ]
1.6000 (estimate) | [Fp ]
211 °C
| [storage temp. ]
Store below +30°C. | [solubility ]
Solubility in methanol gives very faint turbidity. Soluble in DMSO. | [form ]
Crystalline Powder | [pka]
0.06±0.10(Predicted) | [color ]
Yellow | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [BRN ]
475640 | [InChI]
1S/C13H10ClNO/c14-10-6-7-12(15)11(8-10)13(16)9-4-2-1-3-5-9/h1-8H,15H2 | [InChIKey]
ZUWXHHBROGLWNH-UHFFFAOYSA-N | [SMILES]
Nc1ccc(Cl)cc1C(=O)c2ccccc2 | [LogP]
3.16 at 21℃ and pH7 | [CAS DataBase Reference]
719-59-5(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzophenone, 2-amino-5-chloro-(719-59-5) | [EPA Substance Registry System]
719-59-5(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H335-H315-H319 | [Precautionary statements ]
P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R22:Harmful if swallowed.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
PC4933500
| [TSCA ]
Yes | [REACH Registrations]
Active | [HS Code ]
29223900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Aquatic Acute 1
Aquatic Chronic 1 | [Toxicity]
LD50 orally in Rabbit: 10000 mg/kg |
| Hazard Information | Back Directory | [Chemical Properties]
yellow powder | [Uses]
A metabolite of Diazepam; it had a much weaker anticonvulsant effect. | [Synthesis Reference(s)]
Tetrahedron Letters, 35, p. 6811, 1994 DOI: 10.1016/0040-4039(94)85011-9 | [General Description]
2-Amino-5-chlorobenzophenone is a organic nonlinear optical material. | [Synthesis]
(2) 10.0 g of intermediate (II) was added to a three-necked flask containing 50 mL of ethanol, 4.8 g of iron powder was added, and refluxed for 0.5 hours. Subsequently, 1 mL of 6 mol/L sulfuric acid solution was slowly added dropwise. After the dropwise addition, the reaction was continued to reflux for 1 hour. After the reaction was completed, the pH of the reaction solution was adjusted to 8 with NaOH solution and cooled to 50 °C. Add 0.2 g of activated carbon and reflux for 0.5 h. Perform hot filtration into a crystallization flask and cool the crystals. The crystals were washed with ethanol and dried to give 9.60 g of intermediate (III) in 95.1% yield, melting point 96.3-98.2 °C. | [References]
[1] Journal of Chemical Research - Part S, 2002, # 12, p. 601 - 603
[2] Patent: CN108250091, 2018, A. Location in patent: Paragraph 0032; 0034; 0040
[3] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1994, vol. 33, # 7, p. 690 - 691
[4] Patent: CN106083621, 2016, A. Location in patent: Paragraph 0021-0025
[5] Patent: CN107935872, 2018, A. Location in patent: Paragraph 0034-0063; 0067-0074 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|