| Identification | More | [Name]
1-METHYLPIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE | [CAS]
71985-80-3 | [Synonyms]
1-METHYL-4-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE
1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID HCL
1-METHYLPIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE
1-METHYLPIPERIDINO-4-CARBOXYLIC ACID HYDROCHLORIDE
4-CARBOXY-1-METHYL-PIPERIDINE HCL
BIO-FARMA BF002150
RARECHEM AH CK 0139
TIMTEC-BB SBB003751
Methylpiperidincarbonsurehydrochlorid
1-Methyl-piperidine-4-carboxylic acid hydochloride, 98%
N-MethylisonipecoticacidHCl
1-Methylpiperidine-4-carboxylic acid hydrochloride 98%
1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID X HCL
1-Methylpiperidine-4-carboxylic acid hydrochloride ,98% | [Molecular Formula]
C7H14ClNO2 | [MDL Number]
MFCD00190235 | [Molecular Weight]
179.64 | [MOL File]
71985-80-3.mol |
| Chemical Properties | Back Directory | [Melting point ]
226-228°C (dec.) | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
solid | [color ]
Off-white | [Detection Methods]
T,NMR | [InChI]
InChI=1S/C7H13NO2.ClH/c1-8-4-2-6(3-5-8)7(9)10;/h6H,2-5H2,1H3,(H,9,10);1H | [InChIKey]
NLUDEWJJEMHIIL-UHFFFAOYSA-N | [SMILES]
N1(C)CCC(C(O)=O)CC1.[H]Cl | [CAS DataBase Reference]
71985-80-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
Off-white solid | [Synthesis]
The synthesis method of 1-Methylpiperidine-4-carboxylic acid Hydrochloride is shown below: Charge isonipecotic acid, palladium, and purified water into a reaction vessel. Heat the resulting mixture to 90 to 95° C. Charge formic acid and formaldehyde to the vessel. Cool the resulting mixture to 20 to 30° C. Filter the reaction mixture through GF/F. Wash the filter cake with purified water. Concentrate the combined filtrates to ca 2 vol at atmospheric pressure. Adjust the temperature 65 to 75° C. Charge conc—hydrochloric acid to the vessel. Charge acetonitrile to the vessel at ≧70° C. and concentrate the solution to ca 2 vol at atmospheric pressure. Charge acetonitrile to the vessel. Moreover, concentrate the solution at atmospheric pressure to ca 2 vol. Charge acetonitrile to the vessel. Moreover, concentrate the solution at atmospheric pressure to ca 3 vol. Check the water content by KF analysis of the supernatant liquors using AX reagent. Cool the reaction mixture to 20 to 25° C. Stir the reaction mixture for 1 to 2 hours. Filter the reaction mixture. Wash the filter cake with acetonitrile. Dry the product up to 50° C. until ≦0.5% w/w by LOD and ≦0.2% w/w water.
| [References]
[1] Journal of Medicinal Chemistry, 1988, vol. 31, # 4, p. 807 - 814
[2] Patent: WO2011/123654, 2011, A1. Location in patent: Page/Page column 29-30
[3] Patent: WO2010/83384, 2010, A2. Location in patent: Page/Page column 61 |
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